Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.
Institute of Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California 94305, USA.
Nat Commun. 2017 May 11;8:15046. doi: 10.1038/ncomms15046.
The adult mammalian cochlear sensory epithelium houses two major types of cells, mechanosensory hair cells and underlying supporting cells, and lacks regenerative capacity. Recent evidence indicates that a subset of supporting cells can spontaneously regenerate hair cells after ablation only within the first week postparturition. Here in vivo clonal analysis of mouse inner ear cells during development demonstrates clonal relationship between hair and supporting cells in sensory organs. We report the identification in mouse of a previously unknown population of multipotent stem/progenitor cells that are capable of not only contributing to the hair and supporting cells but also to other cell types, including glia, in cochlea undergoing development, maturation and repair in response to damage. These multipotent progenitors originate from Eya1-expressing otic progenitors. Our findings also provide evidence for detectable regenerative potential in the postnatal cochlea beyond 1 week of age.
成年哺乳动物耳蜗感觉上皮包含两种主要类型的细胞，机械敏感的毛细胞和下面的支持细胞，并且缺乏再生能力。最近的证据表明，在产后第一周内，只有一小部分支持细胞在消融后可以自发地再生毛细胞。本文通过对发育过程中小鼠内耳细胞的体内克隆分析，证明了感觉器官中毛细胞和支持细胞之间存在克隆关系。我们报告了在小鼠中发现了一种以前未知的多能干细胞/祖细胞群体，它们不仅能够分化为毛细胞和支持细胞，还能够分化为其他细胞类型，包括在耳蜗中发育、成熟和修复过程中对损伤作出反应的胶质细胞。这些多能祖细胞来源于表达 Eya1 的耳原基祖细胞。我们的研究结果还为出生后耳蜗在 1 周龄以上具有可检测的再生潜能提供了证据。
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