Lee Mary P, Waldhaus Joerg
Department of Otolaryngology-Head and Neck Surgery, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Otolaryngology-Head and Neck Surgery, Kresge Hearing Research Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Mol Cell Neurosci. 2022 May;120:103736. doi: 10.1016/j.mcn.2022.103736. Epub 2022 May 14.
The sensory cells of the inner ear, called hair cells, do not regenerate spontaneously and therefore, hair cell loss and subsequent hearing loss are permanent in humans. Conversely, functional hair cell regeneration can be observed in non-mammalian vertebrate species like birds and fish. Also, during postnatal development in mice, limited regenerative capacity and the potential to isolate stem cells were reported. Together, these findings spurred the interest of current research aiming to investigate the endogenous regenerative potential in mammals. In this review, we summarize current in vitro based approaches and briefly introduce different in vivo model organisms utilized to study hair cell regeneration. Furthermore, we present an overview of the findings that were made synergistically using both, the in vitro and in vivo based tools.
内耳的感觉细胞，即毛细胞，不会自发再生，因此，毛细胞损失及随后的听力损失在人类中是永久性的。相反，在鸟类和鱼类等非哺乳动物脊椎动物物种中可以观察到功能性毛细胞再生。此外，在小鼠出生后的发育过程中，也有报道称其具有有限的再生能力和分离干细胞的潜力。这些发现共同激发了当前旨在研究哺乳动物内源性再生潜力的研究兴趣。在这篇综述中，我们总结了当前基于体外的方法，并简要介绍了用于研究毛细胞再生的不同体内模型生物。此外，我们概述了同时使用基于体外和体内的工具协同得出的研究结果。
