Parnanzone Serena, Serrone Dario, Rossetti Maria Cristina, D'Onofrio Simona, Splendiani Alessandra, Micelli Valeria, Rossi Alessandro, Pacitti Francesca
Department of Biotechnological and Applied Clinical Sciences (DISCAB), University of L'Aquila, Italy.
Department of Biothecnological and Applied Clinical Sciences (DISCAB), Neuroradiological Unit, University of L'Aquila, Italy.
Riv Psichiatr. 2017 Mar-Apr;52(2):49-66. doi: 10.1708/2679.27441.
Schizophrenia is a common, severe and chronically disabling mental illness. Most of MRI studies in schizophrenia suggest the involvement of white matter (WM) pathology in multiple cerebral regions in the neurobiology of this condition. White matter fiber tracts connecting numerous cortical regions have been the focus of a number of studies using a magnetic resonance technique called “Diffusion Tensor Imaging” (DTI). A literature search of published DTI studies was conducted using the major database National Centre for Biotechnology information (NCBI) PubMed (MEDLINE). Our review covers 95 published papers. We summarise the main DTI findings involving the different brain regions in patients affected by or at high-risk for psychosis; we discuss clinical implications of these white matter disruptions and the limitations of current studies, listing the potential confounds and suggesting potential future research directions.
精神分裂症是一种常见、严重且长期致残的精神疾病。大多数关于精神分裂症的磁共振成像（MRI）研究表明，白质（WM）病理学在该疾病的神经生物学中涉及多个脑区。连接众多皮质区域的白质纤维束一直是许多使用一种名为“扩散张量成像”（DTI）的磁共振技术进行研究的重点。我们使用主要数据库美国国立生物技术信息中心（NCBI）的PubMed（医学文献数据库）对已发表的DTI研究进行了文献检索。我们的综述涵盖了95篇已发表的论文。我们总结了涉及受精神病影响或处于高风险状态患者不同脑区的主要DTI研究结果；我们讨论了这些白质破坏的临床意义以及当前研究的局限性，列出了潜在的混杂因素并提出了未来潜在的研究方向。
