Associations of Central Arterial Stiffness With Brain White Matter Integrity and Gray Matter Volume in MRI Across the Adult Lifespan.

BACKGROUND

Central arterial stiffening is associated with brain white matter (WM) damage and gray matter (GM) volume loss in older adults, but little is known about this association from an adult lifespan perspective.

PURPOSE

To investigate the associations of central arterial stiffness with WM microstructural organization, WM lesion load, cortical thickness, and GM volume in healthy adults across the lifespan.

STUDY TYPE

This is a cross-sectional study.

SUBJECTS

A total of 173 healthy adults (22-81 years) were included in this study.

FIELD STRENGTH/SEQUENCE: 3-T, T1-weighted magnetization prepared rapid gradient echo (MPRAGE), single-shot echo-planar imaging diffusion-weighted, and T2-weighted fluid-attenuated inversion recovery (FLAIR) sequences.

ASSESSMENT

The participants underwent measurements of central arterial stiffness using carotid-femoral pulse wave velocity (cfPWV), diffusion tensor imaging (DTI) to measure whole-brain WM microstructural organization with free water (FW) and FW-corrected fractional anisotropy (FA), FLAIR to measure whole-brain WM hyperintensities (WMH), and MPRAGE to measure whole-brain cortical thickness and GM volume. The associations of age and cfPWV with MRI measures were assessed.

STATISTICAL TESTS

Linear regression models to examine the associations of brain WM and GM measures with age, cfPWV, and age × cfPWV interaction after adjusting for sex, education, and intracranial volume (ICV) (voxel-wise and cluster threshold P < 0.05). To understand the direction of the interaction result, the sample was stratified into lower and higher cfPWV groups using a median split of cfPWV.

RESULTS

Age × cfPWV interactions were observed in WM FW, WMH volume, cortical thickness, and GM volume (P < 0.01) such that the positive regression slopes between age, FW, and WMH volume were higher, while the negative regression slopes between age, cortical thickness, and GM volume were lower in those who had higher cfPWV relative to those who had lower cfPWV.

DATA CONCLUSION

Central arterial stiffening may accelerate the age-related deteriorations in GM and WM structure across the adult lifespan.

PLAIN LANGUAGE SUMMARY

Central arterial stiffening is associated with brain white matter (WM) damage and gray matter (GM) volume loss in older adults. We extended this investigation into an adult lifespan perspective by examining the associations of central arterial stiffening with brain structure in adults across age. A total of 172 healthy adults (22-81 years) underwent central arterial stiffening measure using applanation tonometry and brain measurement using MRI. We observed that higher central arterial stiffening may accelerate the age-related deterioration in brain WM and GM structure. These results suggest the importance of maintaining vascular health to slow age-related brain structural changes from an adult lifespan perspective.

LEVEL OF EVIDENCE

4 TECHNICAL EFFICACY: Stage 5.