美味乳菇子实体中的新型薁类倍半萜

New Azulene-Type Sesquiterpenoids from the Fruiting Bodies of Lactarius deliciosus.

作者信息

Feussi Tala Michel, Qin Jianchun, Ndongo Joseph T, Laatsch Hartmut

机构信息

Institute of Organic and Biomolecular Chemistry, University of Goettingen, Tammannstrasse 2, 37077, Göttingen, Germany.

School of Plant Science, Jilin University, Xian Road No. 5333, Changchun, 130062, Jilin, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2017 Jun;7(3):269-273. doi: 10.1007/s13659-017-0130-1. Epub 2017 May 11.

DOI:10.1007/s13659-017-0130-1

PMID:28493207

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5481275/

Abstract

In the H NMR-guided fractionation of extracts from the edible mushroom Lactarius deliciosus, two new azulene-type sesquiterpenoids, 7-isopropenyl-4-methyl-azulene-1-carboxylic acid (1) and 15-hydroxy-3,6-dihydrolactarazulene (2), together with seven known compounds were characterized. Their structures were determined on basis of spectroscopic evidence, as well as by comparing with literature data. Amongst the known metabolites, the C NMR assignment of 15-hydroxy-6,7-dihydrolactarazulene (3) is reported here for the first time. Moreover, 7-acetyl-4-methylazulene-1-carbaldehyde (5) displayed a moderate antibacterial activity against Staphylococcus aureus. *Digital image of L. deliciosus. Retrieved March 17, 2017 from https://upload.wikimedia.org/wikipedia/commons/e/e3/Lactarius_deliciosus_1_(1).jpg .

摘要

在对美味乳菇提取物进行氢核磁共振引导分级分离的过程中，鉴定出了两种新的薁类倍半萜化合物，7-异丙烯基-4-甲基薁-1-羧酸（1）和15-羟基-3,6-二氢乳菇薁（2），以及七种已知化合物。它们的结构是根据光谱证据以及与文献数据对比确定的。在这些已知代谢产物中，15-羟基-6,7-二氢乳菇薁（3）的碳核磁共振归属在此首次报道。此外，7-乙酰基-4-甲基薁-1-甲醛（5）对金黄色葡萄球菌显示出中等抗菌活性。*美味乳菇的数码图像。2017年3月17日从https://upload.wikimedia.org/wikipedia/commons/e/e3/Lactarius_deliciosus_1_(1).jpg获取。