Department of Psychiatry, Queen Mary Hospital, Hong Kong.
Department of Psychiatry, The University of Hong Kong, Hong Kong.
Int J Geriatr Psychiatry. 2018 Jan;33(1):e1-e13. doi: 10.1002/gps.4726. Epub 2017 May 11.
This systematic review and meta-analysis aimed to examine the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive function in older patients with cognitive impairment.
A literature search was performed for articles published in English using the 10 databases (MEDLINE, EMBASE, PsycINFO, INSPEC, the Cumulative Index to Nursing and Allied Health Literature Plus, AMED, Biological Sciences, ClinicalTrials.gov, the Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews) from their inception to May 2016. The primary outcome was cognitive function as measured by the Mini-Mental State Examination or the Alzheimer's Disease Assessment Scale-cognitive subscale.
Seven RCTs were included in the meta-analysis, with a sample of 107 active and 87 sham rTMS. Active rTMS was found to be more effective in improving cognition (Hedges' g = 0.48; 95% confidence interval 0.12 to 0.84).
High-frequency rTMS showed a benefit on cognition amongst older patients with mild to moderate Alzheimer's disease. rTMS was shown to have great potential as a safe and well-tolerated alternative intervention for cognition. Copyright © 2017 John Wiley & Sons, Ltd.
本系统评价和荟萃分析旨在研究重复经颅磁刺激（rTMS）对认知障碍老年患者认知功能的影响。
使用 10 个数据库（MEDLINE、EMBASE、PsycINFO、INSPEC、护理学和联合健康文献累积索引加、AMED、生物科学、ClinicalTrials.gov、Cochrane 对照试验中心注册库和 Cochrane 系统评价数据库），从建库开始至 2016 年 5 月，以英文文献进行检索。主要结局指标是采用简易精神状态检查或阿尔茨海默病评估量表认知分量表测量的认知功能。
荟萃分析纳入了 7 项 RCT，共有 107 例主动 rTMS 和 87 例假刺激 rTMS 样本。主动 rTMS 更有效地改善认知（Hedges' g=0.48；95%置信区间 0.12 至 0.84）。
高频 rTMS 对轻度至中度阿尔茨海默病老年患者的认知功能有益。rTMS 作为一种安全且耐受良好的认知替代干预措施，具有很大的潜力。版权所有 © 2017 约翰威立父子公司
