Department of Chemistry, Technical University of Denmark , Kongens Lyngby DK-2800, Denmark.
Department of Immunology and Microbiology, University of Copenhagen , Copenhagen DK-2200, Denmark.
Chem Rev. 2017 Jun 28;117(12):7811-7856. doi: 10.1021/acs.chemrev.6b00806. Epub 2017 May 11.
N-Acyliminium ions are powerful reactive species for the formation of carbon-carbon and carbon-heteroatom bonds. Strategies relying on intramolecular reactions of N-acyliminium intermediates, also referred to as N-acyliminium ion cyclization reactions, have been employed for the construction of structurally diverse scaffolds, ranging from simple bicyclic skeletons to complex polycyclic systems and natural-product-like compounds. This review aims to provide an overview of cyclization reactions of N-acyliminium ions derived from various precursors for the assembly of structurally diverse scaffolds, covering the literature over the past 12 years (from 2004 to 2015).
N-酰亚胺离子是形成碳-碳和碳-杂原子键的强反应性物种。依赖于 N-酰亚胺中间体的分子内反应的策略，也称为 N-酰亚胺离子环化反应，已被用于构建结构多样的支架，从简单的双环骨架到复杂的多环系统和类似天然产物的化合物。本文综述了过去 12 年（2004 年至 2015 年）中，各种前体制备的 N-酰亚胺离子的环化反应，用于组装结构多样的支架。
