Laboratory of Bioorganic Chemistry, Department of Physics, Università degli Studi di Trento, Via Sommarive 14, 38123 Trento, Italy.
Molecules. 2023 Sep 27;28(19):6821. doi: 10.3390/molecules28196821.
Agelastatin A is a marine alkaloid with potent biological activity. To date, at least 17 different strategies have achieved its total synthesis, along with many analogues. The present study focuses on the acidity stability of some -methyl derivatives of agelastatin A. The study made use of chemical reactions and spectroscopic acquisitions. The chemical structure of some derivatives can undergo a profound rearrangement. The results could shed light on the mechanism of action of agelastatin A and suggest the preparation of analogues with improved pharmacological efficacy.
阿格雷他汀 A 是一种具有强生物活性的海洋生物碱。迄今为止，已经至少有 17 种不同的策略实现了其全合成，以及许多类似物。本研究关注的是阿格雷他汀 A 的一些 -甲基衍生物的酸度稳定性。该研究利用化学反应和光谱采集来进行。一些衍生物的化学结构可能会发生深刻的重排。研究结果可以为阿格雷他汀 A 的作用机制提供线索，并为制备具有改善的药理功效的类似物提供建议。
