通过测试前注射β-内啡肽和氧化震颤素增强记忆保持及其被东莨菪碱逆转。
Retention enhancement by pre-test beta-endorphin and oxotremorine and its reversal by scopolamine.
作者信息
Brioni J D, Izquierdo I
机构信息
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717.
出版信息
Behav Neural Biol. 1988 Nov;50(3):251-4. doi: 10.1016/s0163-1047(88)90922-3.
The pre-test administration of beta-endorphin (0.05 microgram/mouse), oxotremorine sesquifumarate (5.0 micrograms/mouse), or beta-endorphin plus oxotremorine enhanced retention test performance of a conditioned emotional response in mice. The effects were blocked by scopolamine. Scopolamine had no effect of its own. The data suggest that the retention enhancement caused by beta-endorphin may involve the secondary activation of cholinergic mechanisms.
对小鼠预先给予β-内啡肽（0.05微克/只）、延胡索酸奥索震颤素（5.0微克/只）或β-内啡肽加奥索震颤素，可增强小鼠条件性情绪反应的记忆保持测试表现。这些作用被东莨菪碱阻断。东莨菪碱自身无此作用。数据表明，β-内啡肽引起的记忆保持增强可能涉及胆碱能机制的继发性激活。
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