Esparvarinha Mojgan, Nickho Hamid, Mohammadi Hamed, Aghebati-Maleki Leili, Abdolalizadeh Jalal, Majidi Jafar
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Immunology Laboratory, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Pharmacother. 2017 Jul;91:632-644. doi: 10.1016/j.biopha.2017.04.121. Epub 2017 May 7.
Kappa (κ) or lambda (λ) free light chains (FLCs) are produced from B cells during immunoglobulin synthesis. FLCs have been shown to participate in several key processes of immune responses. They are necessary to adjust PMN functions and assist PMN pre-stimulation. Moreover, they cause mast cell degranulation which releases pro-inflammatory mediators and stimulates local inflammatory responses in some conditions such as inflammatory bowel disease (IBD). Having low molecular weights which may straightly be toxic to proximal tubule cells (PTCs), FLCs can also have an important role in renal diseases. In this review we have highlighted the involvement of light chains in the pathogenesis of some inflammatory diseases and discussed their potential to be the targets of therapeutic purposes.
κ（kappa）或λ（lambda）游离轻链（FLCs）在免疫球蛋白合成过程中由B细胞产生。已表明FLCs参与免疫反应的几个关键过程。它们对于调节中性粒细胞功能和协助中性粒细胞预刺激是必需的。此外，它们会导致肥大细胞脱颗粒，释放促炎介质，并在某些情况下（如炎症性肠病（IBD））刺激局部炎症反应。FLCs分子量低，可能直接对近端肾小管细胞（PTCs）有毒性，在肾脏疾病中也可能起重要作用。在本综述中，我们强调了轻链在某些炎症性疾病发病机制中的作用，并讨论了它们作为治疗靶点的潜力。
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