Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Justus Liebig University, Feulgenstr. 12, 35392 Giessen, Germany.
Department of Laboratory Medicine, Paracelsus Medical University and Salzburger Landeskliniken, Strubergasse 21, 5020 Salzburg, Austria.
Medicina (Kaunas). 2022 Oct 24;58(11):1512. doi: 10.3390/medicina58111512.
: The positive implications of using free light chains in diagnosing multiple sclerosis have increasingly gained considerable interest in medical research and the scientific community. It is often presumed that free light chains, particularly kappa and lambda free light chains, are of practical use and are associated with a higher probability of obtaining positive results compared to oligoclonal bands. The primary purpose of the current paper was to conduct a systematic review to assess the up-to-date methods for diagnosing multiple sclerosis using kappa and lambda free light chains. : An organized literature search was performed across four electronic sources, including Google Scholar, Web of Science, Embase, and MEDLINE. The sources analyzed in this systematic review and meta-analysis comprise randomized clinical trials, prospective cohort studies, retrospective studies, controlled clinical trials, and systematic reviews. : The review contains 116 reports that includes 1204 participants. The final selection includes a vast array of preexisting literature concerning the study topic: 35 randomized clinical trials, 21 prospective cohort studies, 19 retrospective studies, 22 controlled clinical trials, and 13 systematic reviews. : The incorporated literature sources provided integral insights into the benefits of free light chain diagnostics for multiple sclerosis. It was also evident that the use of free light chains in the diagnosis of clinically isolated syndrome (CIS) and multiple sclerosis is relatively fast and inexpensive in comparison to other conventional state-of-the-art diagnostic methods, e.g., using oligoclonal bands (OCBs).
: 使用游离轻链诊断多发性硬化症的积极意义在医学研究和科学界引起了越来越多的关注。人们通常认为游离轻链，特别是κ和λ游离轻链，具有实际用途，并且与获得阳性结果的可能性更高相关，而与寡克隆带相比。本研究的主要目的是进行系统评价，以评估使用κ和λ游离轻链诊断多发性硬化症的最新方法。 : 我们在四个电子资源（包括 Google Scholar、Web of Science、Embase 和 MEDLINE）中进行了有组织的文献搜索。本系统评价和荟萃分析中分析的来源包括随机临床试验、前瞻性队列研究、回顾性研究、对照临床试验和系统评价。 : 综述包含 116 份报告，其中包括 1204 名参与者。最终选择包括大量关于研究主题的现有文献：35 项随机临床试验、21 项前瞻性队列研究、19 项回顾性研究、22 项对照临床试验和 13 项系统评价。 : 纳入的文献来源为游离轻链诊断多发性硬化症的优势提供了重要的见解。此外，与其他传统的最先进的诊断方法（例如使用寡克隆带[OCBs]）相比，游离轻链在诊断临床孤立综合征（CIS）和多发性硬化症中的应用相对快速且廉价。
