Department of Dermatology, Far Eastern Memorial Hospital, New Taipei, Taiwan.
Graduate Institute of Applied Science and Engineering, College of Science and Engineering, Fu Jen Catholic University, New Taipei, Taiwan.
Cancer Res Treat. 2018 Apr;50(2):428-435. doi: 10.4143/crt.2017.110. Epub 2017 May 10.
Previous western studies have found Caucasians with skin cancer, either melanoma or nonmelanoma skin cancer (NMSC), have an elevated risk of second primary cancer. Our objective was to assess the risk of second primary cancer in Taiwanese with NMSC.
By using data from Taiwan's National Health Insurance Research Database, we conducted a population-based cohort study to assess the risk of incident second primary cancer in Taiwanese affected by NMSC.
We identified 505 subjects with NMSC and 2,020 matched controls. After adjustment for potential confounders including age, sex, urbanization, and Charlson Comorbidity Index, people who had NMSC had a 1.43-fold (95% confidence interval [CI], 1.05 to 1.96) risk for the development of second primary cancer as comparedwith control group. Menwith NMSC had a 2.99-fold (95% CI, 1.00 to 9.10) risk for second primary cancer involving the lip, oral cavity, and pharynx and a 3.51-fold (95% CI, 1.21 to 10.17) risk for second primary cancer involving the genitourinary organs when compared to the control group. By contrast, women with NMSC did not have an increased risk of second primary cancer.
This study revealed Asians with NMSC have an increased risk of second primary cancer. Our findings can be a useful reference for health care for people diagnosed with NMSC.
先前的西方研究发现，患有皮肤癌（无论是黑色素瘤还是非黑色素瘤皮肤癌[NMSC]）的白种人发生第二原发癌的风险增加。我们的目的是评估台湾 NMSC 患者发生第二原发癌的风险。
通过使用来自台湾全民健康保险研究数据库的数据，我们进行了一项基于人群的队列研究，以评估台湾 NMSC 患者发生第二原发癌的风险。
我们确定了 505 名 NMSC 患者和 2020 名匹配对照。在调整了年龄、性别、城市化和 Charlson 合并症指数等潜在混杂因素后，与对照组相比，患有 NMSC 的人发生第二原发癌的风险增加了 1.43 倍（95%置信区间[CI]，1.05 至 1.96）。与对照组相比，患有 NMSC 的男性发生第二原发癌（涉及唇、口腔和咽）的风险增加了 2.99 倍（95%CI，1.00 至 9.10），发生第二原发癌（涉及泌尿生殖器官）的风险增加了 3.51 倍（95%CI，1.21 至 10.17）。相比之下，患有 NMSC 的女性发生第二原发癌的风险并未增加。
本研究显示亚洲人 NMSC 患者发生第二原发癌的风险增加。我们的研究结果可为诊断为 NMSC 的患者的医疗保健提供有用的参考。
