Department of Applied Chemistry, Graduate School of Engineering, University of Hyogo , 2167 Shosha, Himeji, Hyogo 671-2280, Japan.
Department of Materials Engineering, School of Engineering, The University of Tokyo , 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Langmuir. 2017 May 30;33(21):5236-5244. doi: 10.1021/acs.langmuir.7b00500. Epub 2017 May 18.
Anionic diblock copolymers (PA) composed of biocompatible polybetaine, poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC), and anionic poly(sodium 2-(acrylamido)-2-methylpropanesulfonate) (PAMPS) were synthesized via reversible addition-fragmentation chain transfer (RAFT) radical polymerization. Two types of diblock copolymers (PA and PA) were prepared with different compositions. The PA/CTAB complexes were formed by a stoichiometrically charge-neutralized mixture of anionic PA and cationic cetyltrimethylammonium bromide (CTAB) micelles in water. The complexes prepared using PA and PA were vesicles and micelles, respectively, and were covered with hydrophilic PMPC shells. The complexes dissociated upon addition of NaCl because the complex was maintained through electrostatic interactions. The PA/CTAB vesicles could encapsulate uncharged hydrophilic guest molecules into the interior of the aqueous phase.
由生物相容性聚甜菜碱、聚(2-(甲基丙烯酰氧)乙基磷酸胆碱)(PMPC)和阴离子聚(2-(丙烯酰胺基)-2-甲基丙磺酸) (PAMPS)组成的阴离子两亲嵌段共聚物(PA)通过可逆加成-断裂链转移(RAFT)自由基聚合合成。两种嵌段共聚物(PA 和 PA)具有不同的组成。PA/CTAB 复合物是通过阴离子 PA 和阳离子十六烷基三甲基溴化铵(CTAB)胶束在水中的化学计量电荷中和混合物形成的。使用 PA 和 PA 制备的复合物分别为囊泡和胶束，并且覆盖有亲水性 PMPC 壳。由于复合物通过静电相互作用维持，因此加入 NaCl 后复合物会解离。PA/CTAB 囊泡可以将不带电的亲水性客体分子包封到水相的内部。
