锂对正常男性肾脏对多巴胺前体药物卢多巴反应的影响。
The effect of lithium on the renal response to the dopamine prodrug gludopa in normal man.
作者信息
Jeffrey R F, Macdonald T M, Brown J, Rae P W, Lee M R
机构信息
Department of Clinical Pharmacology, Royal Infirmary, Edinburgh.
出版信息
Br J Clin Pharmacol. 1988 Jun;25(6):725-32. doi: 10.1111/j.1365-2125.1988.tb05259.x.
Abstract
- The effect of oral lithium on the renal response to gamma-L-glutamyl-L-dopa (gludopa, 25 micrograms kg-1 min-1) was investigated in seven normal males. 2. Gludopa at this dose produced an 800-fold increase in urine dopamine excretion. It was natriuretic and suppressed plasma renin activity without altering blood pressure and pulse. 3. Lithium alone increased sodium excretion and stimulated plasma renin activity. However, it abolished the natriuresis produced by gludopa. 4. Gludopa did not significantly affect lithium clearance. 5. This study suggests that lithium interacts with dopamine at the proximal tubule and that the lithium clearance method is not suitable for investigating dopaminergic mechanisms in the kidney.
摘要
- 在7名正常男性中研究了口服锂对肾脏对γ-L-谷氨酰-L-多巴（谷氨酰多巴，25微克/千克·分钟）反应的影响。2. 此剂量的谷氨酰多巴使尿多巴胺排泄量增加了800倍。它具有利钠作用并抑制血浆肾素活性，而不改变血压和脉搏。3. 单独使用锂会增加钠排泄并刺激血浆肾素活性。然而，它消除了谷氨酰多巴产生的利钠作用。4. 谷氨酰多巴对锂清除率无显著影响。5. 本研究表明锂在近端小管与多巴胺相互作用，且锂清除率方法不适用于研究肾脏中的多巴胺能机制。
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