Worth D P, Harvey J N, Brown J, Worral A, Lee M R
Br J Clin Pharmacol. 1986 May;21(5):497-502. doi: 10.1111/j.1365-2125.1986.tb02831.x.
The dopamine pro-drug gamma-L-glutamyl-L-dopa (gludopa) was administered intravenously to six normal subjects at a dose of 12.5 micrograms min-1 kg-1, either with or without the dopamine antagonist domperidone. A control was provided by the intravenous infusion of domperidone and saline on a separate occasion. Intravenous gludopa produced a significant natriuresis, whether administered alone or in combination with domperidone. After gludopa infusion, there was a significant fall in plasma renin activity, an effect which was attenuated significantly by concomitant treatment with domperidone. These observations suggest that blockade of renal DA2 dopamine receptors has little or no effect on gludopa-induced natriuresis, but that at least part of the dopaminergic inhibition of renin release is mediated by renal DA2 receptors.
将多巴胺前体药物γ-L-谷氨酰-L-多巴（谷氨酰多巴）以12.5微克·分钟⁻¹·千克⁻¹的剂量静脉注射给6名正常受试者，给药时有的加用多巴胺拮抗剂多潘立酮，有的不加。在另一个单独的场合，通过静脉输注多潘立酮和生理盐水作为对照。静脉注射谷氨酰多巴，无论单独给药还是与多潘立酮联合给药，均产生显著的利钠作用。输注谷氨酰多巴后，血浆肾素活性显著下降，而多潘立酮的同时治疗可显著减弱这种作用。这些观察结果表明，阻断肾DA2多巴胺受体对谷氨酰多巴诱导的利钠作用几乎没有影响，但多巴胺能对肾素释放的抑制作用至少部分是由肾DA2受体介导的。
