多潘立酮对人体的治疗可抑制静脉注射γ-L-谷氨酰-L-多巴引起的血浆肾素活性下降。
Domperidone treatment in man inhibits the fall in plasma renin activity induced by intravenous gamma-L-glutamyl-L-dopa.
作者信息
Worth D P, Harvey J N, Brown J, Worral A, Lee M R
出版信息
Br J Clin Pharmacol. 1986 May;21(5):497-502. doi: 10.1111/j.1365-2125.1986.tb02831.x.
Abstract
The dopamine pro-drug gamma-L-glutamyl-L-dopa (gludopa) was administered intravenously to six normal subjects at a dose of 12.5 micrograms min-1 kg-1, either with or without the dopamine antagonist domperidone. A control was provided by the intravenous infusion of domperidone and saline on a separate occasion. Intravenous gludopa produced a significant natriuresis, whether administered alone or in combination with domperidone. After gludopa infusion, there was a significant fall in plasma renin activity, an effect which was attenuated significantly by concomitant treatment with domperidone. These observations suggest that blockade of renal DA2 dopamine receptors has little or no effect on gludopa-induced natriuresis, but that at least part of the dopaminergic inhibition of renin release is mediated by renal DA2 receptors.
摘要
将多巴胺前体药物γ-L-谷氨酰-L-多巴（谷氨酰多巴）以12.5微克·分钟⁻¹·千克⁻¹的剂量静脉注射给6名正常受试者，给药时有的加用多巴胺拮抗剂多潘立酮，有的不加。在另一个单独的场合，通过静脉输注多潘立酮和生理盐水作为对照。静脉注射谷氨酰多巴，无论单独给药还是与多潘立酮联合给药，均产生显著的利钠作用。输注谷氨酰多巴后，血浆肾素活性显著下降，而多潘立酮的同时治疗可显著减弱这种作用。这些观察结果表明，阻断肾DA2多巴胺受体对谷氨酰多巴诱导的利钠作用几乎没有影响，但多巴胺能对肾素释放的抑制作用至少部分是由肾DA2受体介导的。
相似文献
1
Domperidone treatment in man inhibits the fall in plasma renin activity induced by intravenous gamma-L-glutamyl-L-dopa.多潘立酮对人体的治疗可抑制静脉注射γ-L-谷氨酰-L-多巴引起的血浆肾素活性下降。
Br J Clin Pharmacol. 1986 May;21(5):497-502. doi: 10.1111/j.1365-2125.1986.tb02831.x.
2
(+)-sulpiride antagonises the renal effects of gamma-L-glutamyl-L-dopa in man.（+）-舒必利可拮抗γ-L-谷氨酰-L-多巴对人体肾脏的作用。
Br J Clin Pharmacol. 1988 Feb;25(2):203-12. doi: 10.1111/j.1365-2125.1988.tb03292.x.
3
A comparison of the renal actions of gamma-L-glutamyl-L-dopa and gamma-L-glutamyl-L-tyrosine in normal man.正常人中γ-L-谷氨酰-L-多巴与γ-L-谷氨酰-L-酪氨酸肾脏作用的比较。
Clin Sci (Lond). 1988 Jan;74(1):37-40. doi: 10.1042/cs0740037.
4
The effect of carbidopa and indomethacin on the renal response to gamma-L-glutamyl-L-dopa in normal man.卡比多巴和吲哚美辛对正常人肾脏对γ-L-谷氨酰-L-多巴反应的影响。
Br J Clin Pharmacol. 1988 Feb;25(2):195-201. doi: 10.1111/j.1365-2125.1988.tb03291.x.
5
Five years' experience with gamma-L-glutamyl-L-dopa: a relatively renally specific dopaminergic prodrug in man.
J Auton Pharmacol. 1990;10 Suppl 1:s103-8. doi: 10.1111/j.1474-8673.1990.tb00235.x.
6
The effect of lithium on the renal response to the dopamine prodrug gludopa in normal man.锂对正常男性肾脏对多巴胺前体药物卢多巴反应的影响。
Br J Clin Pharmacol. 1988 Jun;25(6):725-32. doi: 10.1111/j.1365-2125.1988.tb05259.x.
7
Renal metabolism and effects of the glutamyl derivatives of L-dopa and 5-hydroxytryptophan in man.L-多巴和5-羟色氨酸的谷氨酰衍生物在人体中的肾脏代谢及作用。
Clin Sci (Lond). 1996 Aug;91(2):177-85. doi: 10.1042/cs0910177.
8
gamma-L-Glutamyl-L-dopa is a dopamine pro-drug, relatively specific for the kidney in normal subjects.γ-L-谷氨酰-L-多巴是一种多巴胺前体药物，在正常受试者中对肾脏具有相对特异性。
Clin Sci (Lond). 1985 Aug;69(2):207-14. doi: 10.1042/cs0690207.
9
The renal and haemodynamic effects of a 10 h infusion of glutamyl-L-dopa in normal man.正常男性静脉输注谷氨酰-L-多巴10小时后的肾脏及血流动力学效应。
Br J Clin Pharmacol. 1989 Jun;27(6):811-22. doi: 10.1111/j.1365-2125.1989.tb03444.x.
10
Suppression of noradrenaline spillover by the dopamine prodrug gamma-L-glutamyl-L-dopa: a central effect?多巴胺前药γ-L-谷氨酰-L-多巴对去甲肾上腺素溢出的抑制作用：一种中枢效应？
Hypertens Res. 1995 Jun;18 Suppl 1:S113-8. doi: 10.1291/hypres.18.supplementi_s113.
引用本文的文献
1
Association of Dopamine D1 and D3 Receptor Gene Polymorphisms with Essential Hypertension in 3 Ethnic Groups in China.中国三个民族中多巴胺D1和D3受体基因多态性与原发性高血压的关联
Med Sci Monit Basic Res. 2017 Jun 5;23:234-239. doi: 10.12659/MSMBR.900432.
2
Intrarenal dopaminergic system regulates renin expression.肾内多巴胺能系统调节肾素表达。
Hypertension. 2009 Mar;53(3):564-70. doi: 10.1161/HYPERTENSIONAHA.108.127035. Epub 2009 Jan 12.
3
Comparison of pramipexole with and without domperidone co-administration on alertness, autonomic, and endocrine functions in healthy volunteers.健康志愿者中普拉克索联合与不联合多潘立酮给药对警觉性、自主神经及内分泌功能的比较。
Br J Clin Pharmacol. 2007 Nov;64(5):591-602. doi: 10.1111/j.1365-2125.2007.02938.x. Epub 2007 Jun 19.
4
Role of the renin-angiotensin system in the compensation of quinpirole-induced blood pressure decrease.肾素-血管紧张素系统在喹吡罗诱导的血压降低代偿中的作用。
Naunyn Schmiedebergs Arch Pharmacol. 2003 May;367(5):427-33. doi: 10.1007/s00210-003-0740-5. Epub 2003 Apr 23.
5
Domperidone. A review of its use in diabetic gastropathy.多潘立酮。其在糖尿病性胃病变中的应用综述。
Drugs. 1998 Sep;56(3):429-45. doi: 10.2165/00003495-199856030-00011.
6
Disruption of the dopamine D3 receptor gene produces renin-dependent hypertension.多巴胺D3受体基因的破坏会导致肾素依赖性高血压。
J Clin Invest. 1998 Aug 1;102(3):493-8. doi: 10.1172/JCI3685.
7
(+)-sulpiride antagonises the renal effects of gamma-L-glutamyl-L-dopa in man.（+）-舒必利可拮抗γ-L-谷氨酰-L-多巴对人体肾脏的作用。
Br J Clin Pharmacol. 1988 Feb;25(2):203-12. doi: 10.1111/j.1365-2125.1988.tb03292.x.
8
The effects of intravenous L-dopa on plasma renin activity, renal function, and blood pressure in man.静脉注射左旋多巴对人体血浆肾素活性、肾功能及血压的影响。
Eur J Clin Pharmacol. 1988;35(2):137-41. doi: 10.1007/BF00609242.
本文引用的文献
1
Abolition, by dopamine blockade, of the natriuretic response produced by lower-body positive pressure.通过多巴胺阻断消除下体正压产生的利钠反应。
Clin Sci (Lond). 1982 Oct;63(4):361-6. doi: 10.1042/cs0630361.
2
Conditions for enhancement of renin release by isoproterenol, dopamine, and glucagon.异丙肾上腺素、多巴胺和胰高血糖素增强肾素释放的条件。
Am J Physiol. 1982 Mar;242(3):F267-73. doi: 10.1152/ajprenal.1982.242.3.F267.
3
Effect of domperidone, an extracerebral inhibitor of dopamine receptors, on thyrotropin, prolactin, renin, aldosterone, and 18-hydroxycorticosterone secretion in man.
J Clin Endocrinol Metab. 1982 Apr;54(4):869-71. doi: 10.1210/jcem-54-4-869.
4
Dopaminergic modulation of renin release.
Clin Exp Hypertens (1978). 1981;3(1):15-25. doi: 10.3109/10641968109037165.
5
Renal function and renal afferent and efferent nerve activity.肾功能以及肾传入和传出神经活动。
Am J Physiol. 1982 Nov;243(5):F425-33. doi: 10.1152/ajprenal.1982.243.5.F425.
6
Dopamine receptors and hypertension. Physiologic and pharmacologic implications.多巴胺受体与高血压。生理及药理学意义。
Am J Med. 1984 Oct 5;77(4A):37-44. doi: 10.1016/s0002-9343(84)80036-4.
7
The dopamine receptor antagonist domperidone is also a competitive antagonist at alpha 1-adrenoceptors.
J Pharm Pharmacol. 1980 Jun;32(6):434-5. doi: 10.1111/j.2042-7158.1980.tb12961.x.
8
Effect of hypoglycemia on plasma renin activity in dogs.低血糖对犬血浆肾素活性的影响。
Endocrinology. 1970 Dec;87(6):1306-17. doi: 10.1210/endo-87-6-1306.
9
A computerized cummulative integral method for the precise measurement of the glomerular filtration rate. 1.
Proc Soc Exp Biol Med. 1972 Sep;140(4):1148-55. doi: 10.3181/00379727-140-36630.
10
Effects of dopamine and isoproterenol on renin secretion in the dog.多巴胺和异丙肾上腺素对犬肾素分泌的影响。
Proc Soc Exp Biol Med. 1972 May;140(1):54-7. doi: 10.3181/00379727-140-36394.
Zotero 插件