喹啉衍生物作为强效抗癌剂的合成方法。
Synthetic Methods of Quinoline Derivatives as Potent Anticancer Agents.
作者信息
Sharma Vaibhav, Mehta Dinesh Kumar, Das Rina
机构信息
M.M. College of Pharmacy, M.M. University, Mullana-Ambala, Hr-133207. India.
出版信息
Mini Rev Med Chem. 2017;17(16):1557-1572. doi: 10.2174/1389557517666170510104954.
BACKGROUND
On account of significant biological activities, quinoline derivatives have drawn more attention to the synthesis and biological activities in the search for new therapeutic agents. Several new synthetic approaches have been implemented to derive new molecules from quinoline and all the synthesized molecules showed effective anticancer activity.
METHOD
Some molecules are synthesized using quinolones as precursor reactant, which is another effective product of quinoline, also showing significant activity against malignant tumors. The presence of nitrogen in it and its ability to bind with enzymes like gyrase, topoisomerase II and kinase have also proven it with antitumor activity.
CONCLUSION
This review encapsulates the recent advances in the synthesis and anticancer activity of Quinoline derivatives.
背景
由于具有显著的生物活性，喹啉衍生物在寻找新型治疗药物的过程中，其合成及生物活性受到了更多关注。已采用多种新的合成方法从喹啉衍生出新分子，所有合成的分子均显示出有效的抗癌活性。
方法
一些分子以喹诺酮作为前体反应物进行合成，喹诺酮是喹啉的另一种有效产物，对恶性肿瘤也显示出显著活性。其中氮的存在及其与诸如回旋酶、拓扑异构酶II和激酶等酶结合的能力也证明了其具有抗肿瘤活性。
结论
本综述总结了喹啉衍生物在合成及抗癌活性方面的最新进展。
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