Departamento de Quimica Organica, Programa de Pos-Graduacao em Quimica, Instituto de Quimica, Universidade Federal Fluminense, Outeiro de Sao Joao Batista, s/no, Centro, Niteroi, 24020-141, Rio de Janeiro, Brazil.
Mini Rev Med Chem. 2021;21(16):2209-2226. doi: 10.2174/1389557521666210210155908.
Quinoline and its derivatives comprise an important group of heterocyclic compounds that exhibits a wide range of pharmacological properties such as antibacterial, antiviral, anticancer, antiparasitic, anti-Alzheimer and anticholesterol. The quinoline nucleus is found in the structure of many drugs and rational design in medicinal chemistry for the discovery of novel bioactive molecules. Persistent efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side effects. This review highlights some discoveries on the development of quinoline-based compounds in recent years (2013-2019), focusing on their biological activities, including anticancer, antitubercular, antimalarial, anti-ZIKV, anti-DENV, anti- Leishmania and anti-Alzheimer's disease.
喹啉及其衍生物是一类重要的杂环化合物，具有广泛的药理活性，如抗菌、抗病毒、抗癌、抗寄生虫、抗阿尔茨海默病和降胆固醇。喹啉核存在于许多药物的结构中，在药物化学中对其进行合理设计以发现新的生物活性分子。多年来，人们一直致力于开发具有更好生物活性和最小不良副作用潜力的新型同系物。本文综述了近年来（2013-2019 年）在喹啉类化合物开发方面的一些发现，重点介绍了它们的生物活性，包括抗癌、抗结核、抗疟疾、抗寨卡病毒、抗登革热病毒、抗利什曼原虫和抗阿尔茨海默病。
