阿尔茨海默病、痴呆症与干细胞疗法。
Alzheimer's disease, dementia, and stem cell therapy.
作者信息
Duncan Thomas, Valenzuela Michael
机构信息
Regenerative Neuroscience Group, Brain and Mind Centre & Sydney Medical School, University of Sydney, Sydney, NSW, 2050, Australia.
出版信息
Stem Cell Res Ther. 2017 May 12;8(1):111. doi: 10.1186/s13287-017-0567-5.
Abstract
Alzheimer's disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a condition of neuronal and synaptic loss. Repopulation and regeneration of depleted neuronal circuitry by exogenous stem cells is therefore a rational therapeutic strategy. This review will focus on recent advances in stem cell therapies utilizing animal models of AD, as well as detailing the human clinical trials of stem cell therapies for AD that are currently undergoing development.
摘要
阿尔茨海默病（AD）可以说是我们这个时代最重大的社会、经济和医学危机。AD的特征是进行性神经退行性病理变化，首先是神经元和突触丧失的一种病症。因此，通过外源性干细胞使耗尽的神经回路重新填充和再生是一种合理的治疗策略。本综述将重点关注利用AD动物模型进行干细胞治疗的最新进展，并详细介绍目前正在开展的AD干细胞治疗的人体临床试验。
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