Zhao Xi, Zhang Hui Wen, Zhang Yan, Li Sha, Xu Rui Xia, Sun Jing, Zhu Cheng Gang, Wu Na Qiong, Gao Ying, Guo Yuan Lin, Liu Geng, Dong Qian, Li Jian Jun
Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100037, China.
Biomed Environ Sci. 2017 Apr;30(4):235-243. doi: 10.3967/bes2017.033.
Cigarette smoking is one of the established risk factors of atherosclerotic cardiovascular disease, however, its impact on lipids is not completely understood, especially in the Chinese population. Therefore, this study evaluated the impact of smoking status (non, former, and current smoking) on the distribution of lipoprotein subfractions in untreated patients with angina-like chest pain.
A total of 877 patients were consecutively enrolled and divided into nonsmoking (n = 518), former smoking (n = 103), and current smoking (n = 256) groups. Both low- and high-density lipoprotein cholesterol (LDL-C and HDL-C) subfractions were measured using the Quantimetrix Lipoprint System. The distributions of lipoprotein subfractions were evaluated among the groups.
Compared with nonsmoking subjects, the current smoking group had significantly lower large/medium HDL-C (both P < 0.001) concentration and large HDL subfraction percentage but higher small HDL-C and medium LDL-C concentrations as well as medium LDL subfraction percentage. Importantly, former smoking subjects showed elevated levels of large HDL-C concentration, large HDL particle percentage, and mean LDL particle size and attenuation in small HDL/LDL percentages and small LDL-C concentration, but these levels did not reach the optimal status compared with those of the non-smoking group (data not shown).
Smoking has an adverse impact on the lipoprotein subfractions, presented as lower large HDL particles besides higher small HDL and medium LDL particles, whereas smoking cessation could reverse these change to a certain degree.
吸烟是动脉粥样硬化性心血管疾病已确定的危险因素之一，然而，其对血脂的影响尚未完全明确，尤其是在中国人群中。因此，本研究评估了吸烟状态（从不吸烟、既往吸烟和当前吸烟）对未经治疗的心绞痛样胸痛患者脂蛋白亚组分分布的影响。
连续纳入877例患者，分为不吸烟组（n = 518）、既往吸烟组（n = 103）和当前吸烟组（n = 256）。使用Quantimetrix Lipoprint系统测量低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）亚组分。评估各组脂蛋白亚组分的分布情况。
与不吸烟受试者相比，当前吸烟组的大/中HDL-C浓度（均P < 0.001）和大HDL亚组分百分比显著降低，但小HDL-C和中LDL-C浓度以及中LDL亚组分百分比更高。重要的是，既往吸烟受试者的大HDL-C浓度、大HDL颗粒百分比和平均LDL颗粒大小升高，小HDL/LDL百分比和小LDL-C浓度降低，但与不吸烟组相比，这些水平未达到最佳状态（数据未显示）。
吸烟对脂蛋白亚组分有不利影响，表现为除了小HDL和中LDL颗粒增加外，大HDL颗粒减少，而戒烟可在一定程度上逆转这些变化。
