囊性纤维化患者脓肿分枝杆菌治疗中抗生素方案的相关结局。
Outcomes associated with antibiotic regimens for treatment of Mycobacterium abscessus in cystic fibrosis patients.
作者信息
DaCosta Alison, Jordan Cameron L, Giddings Olivia, Lin Feng-Chang, Gilligan Peter, Esther Charles R
机构信息
Department of Pharmacy Services, University of North Carolina Hospitals, 101 Manning Drive, Chapel Hill, NC 27599, USA.
Pediatric Pulmonology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
出版信息
J Cyst Fibros. 2017 Jul;16(4):483-487. doi: 10.1016/j.jcf.2017.04.013. Epub 2017 May 8.
BACKGROUND
Mycobacterium abscessus infection is associated with declining lung function in cystic fibrosis (CF), but there is little evidence on clinical efficacy to guide treatment.
METHODS
Retrospective review of 37 CF patients treated for M. abscessus respiratory infection at a single center from 2006 to 2014. Outcomes included change in FEV at 30, 60, 90, 180, and 365days after treatment and clearance of M. abscessus from sputum cultures.
RESULTS
Lung function was significantly improved after 30 and 60days of treatment, but not at later time points. Gains were inversely related to starting lung function. Antibiotic choices did not influence outcomes except for greater clearance with clarithromycin.
CONCLUSIONS
Treatment of M. abscessus resulted in short term improvement in lung function that is inversely related to pre-treatment FEV.
背景
脓肿分枝杆菌感染与囊性纤维化（CF）患者肺功能下降有关，但关于指导治疗的临床疗效证据很少。
方法
回顾性分析2006年至2014年在单一中心接受脓肿分枝杆菌呼吸道感染治疗的37例CF患者。结局指标包括治疗后30、60、90、180和365天的第一秒用力呼气容积（FEV）变化以及痰培养中脓肿分枝杆菌清除情况。
结果
治疗30天和60天后肺功能显著改善，但在之后的时间点未改善。改善程度与起始肺功能呈负相关。除克拉霉素清除率更高外，抗生素选择不影响结局。
结论
脓肿分枝杆菌治疗导致肺功能短期改善，且与治疗前FEV呈负相关。
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