一种用于心房颤动的改进QT校正方法及其与窦性心律QT评估的比较。
An Improved QT Correction Method for use in Atrial Fibrillation and a Comparison with the Assessment of QT in Sinus Rhythm.
作者信息
Saluja Deepak, Guyotte Jason A, Reiffel James A
机构信息
Columbia University, College of Physicians and Surgeons, New York, NY.
Emory University School of Medicine, Atlanta, GA.
出版信息
J Atr Fibrillation. 2008 May 16;1(1):9. doi: 10.4022/jafib.9. eCollection 2008 May-Jun.
BACKGROUND
Conventional QT corrections may be inappropriate inatrial fibrillation (AF) due to RR variability and QT lag. Existing formulashave been modified by the formula RRmod to account for this lag. Wedeveloped a novel correction formula for use in AF (QTAF) based onthe slope ∆QT/∆RRmod and report its performance in AF.We also compare QTAF obtained in AF with rate-independentcorrections in NSR.
MATERIALS AND METHODS
A total of 3063 RR/QT pairs from 28 patients with AFwere measured, 22 of whom also had measurements during sinus rhythm. QTc (theBazett equation), QTLC (the Framingham linear correction), and QTAFwere calculated utilizing RRmod, and the rate-independence of eachformula in AF tested. Mean QTAF values in AF were compared to QTintervals corrected with QTLC in normal sinus rhythm.
RESULTS
∆QTc/∆RRmod and∆QTLC/∆RRmod slopes were significantlynon-zero whereas ∆QTAF/∆RRmod was not. QTLCand QTc corrections were imperfect at extremes of RRmod whileQTAF was constant. QTAF corrections in AF were shorterthan QTc or QTLC corrections in NSR.
CONCLUSIONS
QTAF is a novel QT correction with adefined relationship to correction in NSR that performs better than existingstrategies.
背景
由于RR变异性和QT延迟，传统的QT校正方法在心房颤动（AF）中可能并不适用。现有的公式已通过RRmod公式进行了修正，以考虑这种延迟。我们基于斜率∆QT/∆RRmod开发了一种用于AF的新型校正公式（QTAF），并报告了其在AF中的性能。我们还将AF中获得的QTAF与正常窦性心律（NSR）中与心率无关的校正进行了比较。
材料与方法
共测量了28例AF患者的3063对RR/QT，其中22例患者在窦性心律期间也进行了测量。利用RRmod计算QTc（Bazett方程）、QTLC（弗雷明汉姆线性校正）和QTAF，并测试每个公式在AF中的心率独立性。将AF中的平均QTAF值与正常窦性心律中用QTLC校正的QT间期进行比较。
结果
∆QTc/∆RRmod和∆QTLC/∆RRmod斜率显著非零，而∆QTAF/∆RRmod并非如此。在RRmod的极端值时，QTLC和QTc校正并不完美，而QTAF是恒定的。AF中的QTAF校正比NSR中的QTc或QTLC校正短。
结论
QTAF是一种新型的QT校正方法，与NSR中的校正具有明确的关系，其性能优于现有策略。
Zotero 插件