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本文引用的文献

1
Association of plasma phospholipid long-chain ω-3 fatty acids with incident atrial fibrillation in older adults: the cardiovascular health study.血浆磷脂长链 ω-3 脂肪酸与老年人心房颤动事件的关系：心血管健康研究。
Circulation. 2012 Mar 6;125(9):1084-93. doi: 10.1161/CIRCULATIONAHA.111.062653. Epub 2012 Jan 26.
2
N-3 polyunsaturated fatty acids reduces post-operative atrial fibrillation incidence in patients undergoing "on-pump" coronary artery bypass graft surgery.N-3多不饱和脂肪酸可降低接受“体外循环”冠状动脉搭桥手术患者的术后房颤发生率。
Monaldi Arch Chest Dis. 2011 Jun;76(2):93-8. doi: 10.4081/monaldi.2011.196.
3
Long-term omega-3 polyunsaturated fatty acid supplementation reduces the recurrence of persistent atrial fibrillation after electrical cardioversion.长期服用ω-3 多不饱和脂肪酸可降低电复律后持续性心房颤动的复发率。
Heart Rhythm. 2012 Apr;9(4):483-91. doi: 10.1016/j.hrthm.2011.11.034. Epub 2011 Nov 23.
4
Do omega-3 fatty acids prevent atrial fibrillation after open heart surgery? A meta-analysis of randomized controlled trials.ω-3 脂肪酸能否预防心脏直视手术后的心房颤动？一项随机对照试验的荟萃分析。
Clinics (Sao Paulo). 2011;66(11):1923-8. doi: 10.1590/s1807-59322011001100012.
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Fish oil for secondary prevention of atrial fibrillation: should we still believe in its antiarrhythmic effect?
Circulation. 2011 Sep 6;124(10):1093-6. doi: 10.1161/CIRCULATIONAHA.111.048140.
6
n-3 polyunsaturated fatty acids in the prevention of atrial fibrillation recurrences after electrical cardioversion: a prospective, randomized study.n-3 多不饱和脂肪酸预防电复律后心房颤动复发的前瞻性随机研究。
Circulation. 2011 Sep 6;124(10):1100-6. doi: 10.1161/CIRCULATIONAHA.111.022194. Epub 2011 Aug 15.
7
Effect of dietary fish oil on atrial fibrillation after cardiac surgery.膳食鱼油对心脏手术后心房颤动的影响。
Am J Cardiol. 2011 Sep 15;108(6):851-6. doi: 10.1016/j.amjcard.2011.04.036. Epub 2011 Jul 15.
8
Effects of chronic omega-3 polyunsaturated fatty acid supplementation on human pulmonary vein and left atrial electrophysiology in paroxysmal atrial fibrillation.慢性ω-3 多不饱和脂肪酸补充对阵发性心房颤动患者肺静脉和左心房电生理的影响。
Am J Cardiol. 2011 Aug 15;108(4):531-5. doi: 10.1016/j.amjcard.2011.03.082. Epub 2011 May 31.
9
Failure of omega-3 fatty acids in atrial fibrillation? No deficiency of highly unsaturated fatty acids in the absence of heart failure.
Europace. 2011 Sep;13(9):1357; author reply 1357-8. doi: 10.1093/europace/eur149. Epub 2011 May 11.
10
N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study.N-3多不饱和脂肪酸给药不能降低电复律后房颤复发率及炎症反应：一项前瞻性随机研究
Anadolu Kardiyol Derg. 2011 Jun;11(4):305-9. doi: 10.5152/akd.2011.080. Epub 2011 May 5.

医生是否应继续向心房颤动患者推荐鱼油？

Should Physicians Continue to Recommend Fish Oil for Patients with Atrial Fibrillation?

作者信息

Robinson Victoria M, Kowey Peter R

机构信息

The University of Edinburgh, Edinburgh, United Kingdom.

Lankenau Medical Center and Institute for Medical Research, and the Thomas Jefferson University, Philadelphia, United States of America.

出版信息

J Atr Fibrillation. 2012 Oct 6;5(3):593. doi: 10.4022/jafib.593. eCollection 2012 Oct-Nov.

DOI:10.4022/jafib.593
PMID:28496771
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5153211/
Abstract

Many physicians recommend the use of fish oil or omega-3 polyunsaturated fatty acids (n-3 PUFA) in atrial fibrillation (AF) patients. N-3 PUFA have demonstrated anti-fibrillatory properties in several animal studies, however, data regarding their efficacy in preventing AF in humans have been mixed. This article critically reviews studies that have investigated the use of n-3 PUFA for the secondary prevention of paroxysmal and persistent AF and the primary prevention of post-operative AF. We conclude that n-3 PUFA should no longer be recommended for use in any of these AF subtypes until more data are available.

摘要

许多医生建议心房颤动（AF）患者使用鱼油或ω-3多不饱和脂肪酸（n-3 PUFA）。在多项动物研究中，n-3 PUFA已显示出抗纤颤特性，然而，关于其在预防人类房颤方面疗效的数据却参差不齐。本文对研究n-3 PUFA用于阵发性和持续性房颤二级预防以及术后房颤一级预防的研究进行了批判性综述。我们得出结论，在获得更多数据之前，不应再推荐n-3 PUFA用于任何这些房颤亚型。