连接蛋白重塑与心房颤动有关。
Connexin Remodeling Contributes to Atrial Fibrillation.
作者信息
Jennings Michelle M, Donahue J Kevin
机构信息
Case Western Reserve University School of Medicine, MetroHealth Campus.
出版信息
J Atr Fibrillation. 2013 Aug 31;6(2):839. doi: 10.4022/jafib.839. eCollection 2013 Aug-Sep.
Abstract
Atrial fibrillation significantly contributes to mortality and morbidity through increased risk of stroke, heart failure and myocardial infarction. Investigations of mechanisms responsible for the development and maintenance of atrial fibrillation have highlighted the importance of gap junctional remodeling. Connexins 40 and 43, the major atrial gap junctional proteins, undergo considerable alterations in expression and localization in atrial fibrillation, creating an environment conducive to sustained reentry. Atrial fibrillation is initiated and/or maintained in this reentrant substrate. This review will focus on connexin remodeling in the context of underlying mechanism and possible therapeutic target for atrial fibrillation.
摘要
心房颤动通过增加中风、心力衰竭和心肌梗死的风险，显著导致死亡率和发病率上升。对心房颤动发生和维持机制的研究突出了缝隙连接重塑的重要性。连接蛋白40和43是主要的心房缝隙连接蛋白，在心房颤动时其表达和定位会发生相当大的改变，从而营造出有利于持续折返的环境。心房颤动在这种折返基质中起始和/或维持。本综述将聚焦于在心房颤动潜在机制及可能治疗靶点背景下的连接蛋白重塑。
相似文献
1
Connexin Remodeling Contributes to Atrial Fibrillation.连接蛋白重塑与心房颤动有关。
J Atr Fibrillation. 2013 Aug 31;6(2):839. doi: 10.4022/jafib.839. eCollection 2013 Aug-Sep.
2
Role of the calpain system in pulmonary vein connexin remodeling in dogs with atrial fibrillation.钙蛋白酶系统在心房颤动犬肺静脉连接蛋白重塑中的作用
Cardiology. 2009;112(1):22-30. doi: 10.1159/000137694. Epub 2008 Jun 25.
3
Gap junctional remodeling in relation to stabilization of atrial fibrillation in the goat.山羊心房颤动稳定化过程中的缝隙连接重塑
Cardiovasc Res. 2000 Jun;46(3):476-86. doi: 10.1016/s0008-6363(00)00026-2.
4
Relationship between connexins and atrial activation during human atrial fibrillation.人类心房颤动期间连接蛋白与心房激活之间的关系。
J Cardiovasc Electrophysiol. 2004 Feb;15(2):206-16. doi: 10.1046/j.1540-8167.2004.03280.x.
5
Cardiac connexins as candidate genes for idiopathic atrial fibrillation.心脏连接蛋白作为特发性心房颤动的候选基因。
Curr Opin Cardiol. 2006 May;21(3):155-8. doi: 10.1097/01.hco.0000221574.95383.6f.
6
Relationship between connexin expression and gap-junction resistivity in human atrial myocardium.缝隙连接蛋白表达与人心房肌缝隙连接电阻之间的关系。
Circ Arrhythm Electrophysiol. 2014 Apr;7(2):321-9. doi: 10.1161/CIRCEP.113.000606. Epub 2014 Mar 7.
7
The Connexin40A96S mutation from a patient with atrial fibrillation causes decreased atrial conduction velocities and sustained episodes of induced atrial fibrillation in mice.携带有心房颤动患者的 Connexin40A96S 突变的小鼠，其心房传导速度降低，并伴有持续的诱导性心房颤动发作。
J Mol Cell Cardiol. 2013 Dec;65:19-32. doi: 10.1016/j.yjmcc.2013.09.008. Epub 2013 Sep 21.
8
Pharmacological approaches in the treatment of atrial fibrillation.心房颤动治疗中的药理学方法。
Curr Med Chem. 2004 Jan;11(1):13-28. doi: 10.2174/0929867043456241.
9
[Study on the remodeling of myocardial gap junctional protein connexin-40 of chronic atrial fibrillation in rheumatic heart valve disease].[风湿性心脏瓣膜病慢性心房颤动心肌缝隙连接蛋白连接蛋白-40重塑的研究]
Zhonghua Yi Xue Za Zhi. 2004 Oct 17;84(20):1714-5.
10
Changes in connexin expression and the atrial fibrillation substrate in congestive heart failure.充血性心力衰竭中连接蛋白表达及心房颤动基质的变化
Circ Res. 2009 Dec 4;105(12):1213-22. doi: 10.1161/CIRCRESAHA.108.183400. Epub 2009 Oct 29.
引用本文的文献
1
Morphological variations of the interatrial septum and potential implications in equine cardiology.马心脏学中房间隔的形态学变异及潜在影响
Sci Rep. 2025 May 12;15(1):16500. doi: 10.1038/s41598-025-01387-3.
2
The impact of atrial voltage and conduction velocity phenotypes on atrial fibrillation recurrence.心房电压和传导速度表型对房颤复发的影响。
Front Cardiovasc Med. 2024 Dec 16;11:1427841. doi: 10.3389/fcvm.2024.1427841. eCollection 2024.
3
Atrial Fibrillation and Underlying Structural and Electrophysiological Heterogeneity.心房颤动及潜在的结构和电生理异质性。
Int J Mol Sci. 2024 Sep 23;25(18):10193. doi: 10.3390/ijms251810193.
4
Oxidative stress and atrial fibrillation.氧化应激与心房颤动。
J Mol Cell Cardiol. 2024 Nov;196:141-151. doi: 10.1016/j.yjmcc.2024.09.011. Epub 2024 Sep 21.
5
Gene therapy for atrial fibrillation.基因治疗心房颤动。
J Mol Cell Cardiol. 2024 Nov;196:84-93. doi: 10.1016/j.yjmcc.2024.09.004. Epub 2024 Sep 11.
6
Enhancing Treatment Outcomes in Atrial Fibrillation: A Contemporary Literature Review of the Impact of Optimizing Patient Well-Being in Treatment Management.改善心房颤动的治疗效果：关于在治疗管理中优化患者健康状况影响的当代文献综述
Cureus. 2024 Jun 13;16(6):e62321. doi: 10.7759/cureus.62321. eCollection 2024 Jun.
7
Synergistic Effects of Weight Loss and Catheter Ablation: Can microRNAs Serve as Predictive Biomarkers for the Prevention of Atrial Fibrillation Recurrence?减肥与导管消融联合治疗的协同效应：微小 RNA 能否作为预防心房颤动复发的预测性生物标志物？
Int J Mol Sci. 2024 Apr 25;25(9):4689. doi: 10.3390/ijms25094689.
8
Cellular and Molecular Mechanisms of MEK1 Inhibitor-Induced Cardiotoxicity.MEK1抑制剂诱导心脏毒性的细胞和分子机制
JACC CardioOncol. 2022 Nov 15;4(4):535-548. doi: 10.1016/j.jaccao.2022.07.009. eCollection 2022 Nov.
9
The Role of Epicardial Adipose Tissue in the Development of Atrial Fibrillation, Coronary Artery Disease and Chronic Heart Failure in the Context of Obesity and Type 2 Diabetes Mellitus: A Narrative Review.肥胖与2型糖尿病背景下，心外膜脂肪组织在房颤、冠状动脉疾病和慢性心力衰竭发生发展中的作用：一项叙述性综述
J Cardiovasc Dev Dis. 2022 Jul 5;9(7):217. doi: 10.3390/jcdd9070217.
10
New Insights on the Role of Connexins and Gap Junctions Channels in Adipose Tissue and Obesity.关于连接蛋白和缝隙连接通道在脂肪组织和肥胖中的作用的新见解。
Int J Mol Sci. 2021 Nov 10;22(22):12145. doi: 10.3390/ijms222212145.
本文引用的文献
1
Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts.松弛素通过逆转纤维化和心肌细胞肥大，增加传导速度和钠电流，从而抑制自发性高血压大鼠的心房颤动。
Circ Res. 2013 Jul 19;113(3):313-21. doi: 10.1161/CIRCRESAHA.113.301646. Epub 2013 Jun 7.
2
Cryoballoon ablation of paroxysmal atrial fibrillation: 5-year outcome after single procedure and predictors of success.冷冻球囊消融治疗阵发性心房颤动：单次手术 5 年结果及疗效预测因素。
Europace. 2013 Aug;15(8):1143-9. doi: 10.1093/europace/eut021. Epub 2013 Feb 17.
3
Low prevalence of connexin-40 gene variants in atrial tissues and blood from atrial fibrillation subjects.心房颤动患者心房组织和血液中连接蛋白 40 基因变异的低发生率。
BMC Med Genet. 2012 Nov 7;13:102. doi: 10.1186/1471-2350-13-102.
4
Acute termination of human atrial fibrillation by identification and catheter ablation of localized rotors and sources: first multicenter experience of focal impulse and rotor modulation (FIRM) ablation.经鉴定和导管消融局部转子和病灶实现人类心房颤动的急性终止：聚焦脉冲和转子调制（FIRM）消融的首次多中心经验。
J Cardiovasc Electrophysiol. 2012 Dec;23(12):1277-85. doi: 10.1111/jce.12000. Epub 2012 Nov 6.
5
Initial experience with magnetic resonance imaging of atrial scar and co-registration with electroanatomic voltage mapping during atrial fibrillation: success and limitations.心房瘢痕的磁共振成像与心房颤动时电激动标测的同机配准：初步经验及局限性。
Heart Rhythm. 2012 Dec;9(12):2003-9. doi: 10.1016/j.hrthm.2012.08.039. Epub 2012 Aug 30.
6
Treatment of atrial fibrillation by the ablation of localized sources: CONFIRM (Conventional Ablation for Atrial Fibrillation With or Without Focal Impulse and Rotor Modulation) trial.经导管消融局部起源治疗心房颤动：CONFIRM（房颤常规消融伴或不伴局灶激动和转子调制）试验。
J Am Coll Cardiol. 2012 Aug 14;60(7):628-36. doi: 10.1016/j.jacc.2012.05.022. Epub 2012 Jul 18.
7
Connexin gene transfer preserves conduction velocity and prevents atrial fibrillation.缝隙连接基因转移可维持传导速度并预防心房颤动。
Circulation. 2012 Jan 17;125(2):216-25. doi: 10.1161/CIRCULATIONAHA.111.053272. Epub 2011 Dec 8.
8
Atrial fibrillation pathophysiology: implications for management.心房颤动的病理生理学：对管理的启示。
Circulation. 2011 Nov 15;124(20):2264-74. doi: 10.1161/CIRCULATIONAHA.111.019893.
9
Connexin 43 gene therapy prevents persistent atrial fibrillation in a porcine model.缝隙连接蛋白 43 基因治疗可预防猪持续性心房颤动
Cardiovasc Res. 2011 Nov 1;92(2):218-25. doi: 10.1093/cvr/cvr209. Epub 2011 Jul 28.
10
Effects of metoprolol therapy on cardiac gap junction remodelling and conduction in human chronic atrial fibrillation.美托洛尔治疗对人类慢性心房颤动中心脏缝隙连接重构和传导的影响。
Br J Pharmacol. 2011 Sep;164(2b):607-16. doi: 10.1111/j.1476-5381.2011.01460.x.
Zotero 插件