Kashimura M, Kondo M, Abe T, Shinohara M, Baba S
Dept. of Obstet. & Gyne., Univ. of Occupational and Environmental Health.
Gan No Rinsho. 1988 Nov;34(14):2015-8.
Melphalan is widely used in the chemotherapeutic treatment of an ovarian cancer. Bone marrow depression, nail change, hypersensitivity, chronic pulmonary fibrosis, and nausea and vomiting, are the side effects reported as a result of the toxicity of Melphalan. So far as we know, renal toxicity caused by Melphalan has not been reported in the past literature. A case of acute renal failure induced by Melphalan in a patient with 3rd stage ovarian cancer is presented in this paper. This therefore is the first report of renal toxicity caused by Melphalan.
美法仑广泛用于卵巢癌的化疗治疗。骨髓抑制、指甲改变、超敏反应、慢性肺纤维化以及恶心和呕吐,是报道的美法仑毒性导致的副作用。据我们所知,过去的文献中尚未报道美法仑引起的肾毒性。本文报告了1例3期卵巢癌患者因美法仑诱发急性肾衰竭的病例。因此,这是美法仑引起肾毒性的首例报告。