Aggarwal Jaiprakash, Chakraborty Santam, Ghosh Laskar Sarbani, Patil Vijay M, Prabhash Kumar, Bhattacharya Atanu, Noronha Vanita, Purandare Nilendu C, Joshi Amit, Mummudi Naveen, Arora Jitendra, Badhe Rupali
Department of Radiation Oncology, Tata Memorial Hospital, Mumbai, India.
Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India.
Cureus. 2017 Apr 10;9(4):e1149. doi: 10.7759/cureus.1149.
Reference data for European Organization for Research and Treatment of Cancer (EORTC) quality of life questionnaires do not include studies from the Indian subcontinent. The objective of the current study was to establish a reference dataset for Indian patients of non-small cell lung cancer (NSCLC) presenting with brain metastases (BM).
One hundred forty patients with NSCLC with BM treated between 2012-2015 were registered in a prospective cohort study (CTRI/2013/01/003299). The baseline quality of life was evaluated using the EORTC general quality of life questionnaire QLQ-C30 and lung cancer specific module LC13. Minimum important difference (MID) scores for individual domains of the EORTC QLQ-C30 and LC13 questionnaires were derived (MID = 0.2 x standard deviation) from the reference data for patients with recurrent/metastatic lung cancers. In addition, a systematic review was conducted to identify studies reporting baseline quality of life scores for recurrent/metastatic NSCLC.
Scores of several functional as well as symptom scales in the current NSCLC population differed by more than the MID from the baseline mean scores in the reference EORTC population as well as that reported from other studies. Differences in mean score from the EORTC reference data ranged from 6.2 and 9.4 points for the role functioning and cognitive functioning domains. In the symptom scales, the largest differences were observed for the financial difficulties (23.9) scores for the QLQ-C30 and peripheral neuropathy (21.7) for LC13 questionnaires.
The current study demonstrates that baseline reference scores need to be established for patients from the Indian subcontinent. The findings from the current study have important implications for studies employing quality of life (QOL) assessment in the Indian NSCLC patient population.
欧洲癌症研究与治疗组织（EORTC）生活质量问卷的参考数据不包括来自印度次大陆的研究。本研究的目的是为患有脑转移（BM）的非小细胞肺癌（NSCLC）印度患者建立一个参考数据集。
2012年至2015年期间接受治疗的140例患有BM的NSCLC患者被纳入一项前瞻性队列研究（CTRI/2013/01/003299）。使用EORTC通用生活质量问卷QLQ-C30和肺癌特异性模块LC13评估基线生活质量。EORTC QLQ-C30和LC13问卷各领域的最小重要差异（MID）分数（MID = 0.2×标准差）来自复发/转移性肺癌患者的参考数据。此外，进行了一项系统评价，以确定报告复发/转移性NSCLC基线生活质量分数的研究。
当前NSCLC患者群体中几个功能量表和症状量表的得分与EORTC参考人群的基线平均得分以及其他研究报告的得分相比，差异超过MID。与EORTC参考数据相比，角色功能和认知功能领域的平均得分差异在6.2至9.4分之间。在症状量表中，QLQ-C30的经济困难得分（23.9）和LC13问卷的周围神经病变得分（21.7）差异最大。
本研究表明，需要为来自印度次大陆的患者建立基线参考分数。本研究的结果对在印度NSCLC患者群体中采用生活质量（QOL）评估的研究具有重要意义。
