Dubashi B, Vidhubala E, Cyriac S, Sagar T G
Department of Medical Oncology, Cancer Institute WIA, 18 Sardar Patel Road, Guindy, Chennai 600 036, India.
Indian J Cancer. 2010 Apr-Jun;47(2):142-7. doi: 10.4103/0019-509X.63005.
The incidence of breast cancer in young patients less than 35 years is less than 1%. The physical and psychosocial morbidity may affect their ability to successfully function in their social roles. Hence we studied the quality of life (QOL) issues in this subset.
Younger women with age less than 35 years, diagnosed with non-metastatic breast cancer at our Institute, from 1995 to 2005, were included in the study. Quality of life issues were studied during the follow-up using EORTC QOL C30 and BR23. Descriptive and inferential statistics were used in order to analyze the data.
A total of 51 patients were included for the study. The mean age at diagnosis was 30 years. The effect of breast cancer on the occupation and marital status was minimal. The global health status and the functional scores were high, while the overall sexual function was lower. The global health status was higher in the mastectomy group. The arm symptoms (P = 0.027) and pain were higher in the Breast conservation surgery (BCS) group. The sexual symptoms appeared to be higher in the ovary ablated group when compared to the ovary preserved group. The sexual functional scores (P = 0.02) and sexual enjoyment scores (P = 0.003) were better in the mastectomy group.
The overall QOL in younger patients with breast cancer appeared to be good. The QOL and sexual function were marginally worse in the breast conservation group when compared to mastectomy group.
35岁以下年轻患者的乳腺癌发病率低于1%。身体和心理社会发病率可能会影响他们在社会角色中成功发挥作用的能力。因此，我们研究了这一亚组患者的生活质量（QOL）问题。
本研究纳入了1995年至2005年期间在我院诊断为非转移性乳腺癌的年龄小于35岁的年轻女性。在随访期间使用欧洲癌症研究与治疗组织（EORTC）QOL C30和BR23研究生活质量问题。使用描述性和推断性统计分析数据。
共有51名患者纳入本研究。诊断时的平均年龄为30岁。乳腺癌对职业和婚姻状况的影响最小。总体健康状况和功能评分较高，而总体性功能较低。乳房切除术组的总体健康状况较高。保乳手术（BCS）组的手臂症状（P = 0.027）和疼痛较高。与保留卵巢组相比，卵巢切除组的性症状似乎更高。乳房切除术组的性功能评分（P = 0.02）和性愉悦评分（P = 0.003）更好。
年轻乳腺癌患者的总体生活质量似乎良好。与乳房切除术组相比，保乳组的生活质量和性功能略差。
