Jiang Jue, Lv Xiang, Liang Bing, Jiang Hong
Department of Anesthesiology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Zhizaoju Road, 639, Shanghai, 200011, China.
Neurol Sci. 2017 Aug;38(8):1391-1392. doi: 10.1007/s10072-017-2962-1. Epub 2017 May 11.
Signaling pathways of tumor necrosis factor-α (TNF-α) and insulin-like growth factor-I (IGF-I) are found to be functionally interrelated in some experimental studies. IGF-I may be involved in the pathogenesis of postoperative cognitive dysfunction (POCD). In order to investigate the possible interaction of TNF-α and IGF-I in POCD, the plasma levels of IGF-I and TNF-α were determined in 44 patients under general anesthesia. As compared with non-POCD patients, POCD patients showed increased TNF-α and decreased IGF-I levels in plasma, as well as a significant negative correlation between TNF-α and IGF-I values. The present results suggest that interaction of increased TNF-α levels and decreased IGF-1 levels might lead to a vicious circle, which may contribute to POCD.
在一些实验研究中发现，肿瘤坏死因子-α（TNF-α）和胰岛素样生长因子-I（IGF-I）的信号通路在功能上相互关联。IGF-I可能参与术后认知功能障碍（POCD）的发病机制。为了研究TNF-α和IGF-I在POCD中可能的相互作用，对44例接受全身麻醉的患者测定了血浆中IGF-I和TNF-α的水平。与非POCD患者相比，POCD患者血浆中TNF-α升高，IGF-I水平降低，且TNF-α与IGF-I值之间存在显著的负相关。目前的结果表明，TNF-α水平升高和IGF-1水平降低之间的相互作用可能导致恶性循环，这可能促成POCD。
