Davick Jonathan J, Mutgi Krishna A J, Wanat Karolyn A, Link Brian K, Liu Vincent
Department of Pathology, University of Virginia, Charlottesville, Virginia.
Department of Dermatology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
J Cutan Pathol. 2017 Aug;44(8):703-712. doi: 10.1111/cup.12961. Epub 2017 Jun 13.
CD8-positive, CD30-positive cutaneous lymphoproliferative disorders constitute a rare subset of T-cell lymphoproliferative conditions, including variants of primary cutaneous anaplastic large cell lymphoma (ALCL), mycosis fungoides, lymphomatoid papulosis type D, cutaneous gamma-delta T-cell lymphoma and cutaneous peripheral T-cell lymphoma. These entities share overlapping clinical, histopathologic and immunophenotypic features, presenting both a clinical and pathological diagnostic challenge. Presented here is a 73-year-old man with a disseminated, indolent CD30+, CD8+ cutaneous lymphoproliferative disorder with overlapping clinical and histopathological features of both mycosis fungoides and primary cutaneous ALCL, as well as features of lymphomatoid papulosis. To our knowledge, this is the first case of a generalized CD8+, CD30+ eruption with features of both mycosis fungoides and primary cutaneous ALCL arising following an episode of solitary primary cutaneous CD8-positive ALCL.
CD8 阳性、CD30 阳性皮肤淋巴增殖性疾病是 T 细胞淋巴增殖性疾病的一个罕见子集，包括原发性皮肤间变性大细胞淋巴瘤（ALCL）的变体、蕈样肉芽肿、D 型淋巴瘤样丘疹病、皮肤γ-δ T 细胞淋巴瘤和皮肤外周 T 细胞淋巴瘤。这些实体具有重叠的临床、组织病理学和免疫表型特征，给临床和病理诊断带来了挑战。本文报告一名 73 岁男性，患有播散性、惰性 CD30 +、CD8 +皮肤淋巴增殖性疾病，具有蕈样肉芽肿和原发性皮肤 ALCL 的重叠临床和组织病理学特征，以及淋巴瘤样丘疹病的特征。据我们所知，这是首例在单发原发性皮肤 CD8 阳性 ALCL 发作后出现具有蕈样肉芽肿和原发性皮肤 ALCL 特征的全身性 CD8 +、CD30 +皮疹的病例。
