Brown Ryanne A, Fernandez-Pol Sebastian, Kim Jinah
Department of Pathology, Stanford University School of Medicine, Stanford, California.
Department of Dermatology, Stanford University School of Medicine, Stanford, California.
J Cutan Pathol. 2017 Jun;44(6):570-577. doi: 10.1111/cup.12937. Epub 2017 Apr 25.
Primary cutaneous anaplastic large cell lymphoma (PC-ALCL) is a CD30+ lymphoproliferative disorder (LPD) of the skin with a relatively good prognosis in the absence of high-stage disease. CD30+ LPDs comprise approximately 25%-30% of primary cutaneous lymphomas and as a group represent the second most common clonal T-cell neoplasm of the skin behind mycosis fungoides. Diagnosis of PC-ALCL relies strongly on clinicopathologic correlation given the potential morphologic, clinical and molecular overlap with the other cutaneous CD30+ LPD, lymphomatoid papulosis, and more aggressive hematolymphoid neoplasms.
原发性皮肤间变性大细胞淋巴瘤（PC-ALCL）是一种皮肤的CD30+淋巴增殖性疾病（LPD），在无晚期疾病的情况下预后相对较好。CD30+ LPD约占原发性皮肤淋巴瘤的25%-30%，作为一个群体，是仅次于蕈样肉芽肿的第二常见的皮肤克隆性T细胞肿瘤。鉴于PC-ALCL在形态学、临床和分子方面可能与其他皮肤CD30+ LPD、淋巴瘤样丘疹病以及更具侵袭性的血液淋巴系统肿瘤存在重叠，其诊断在很大程度上依赖于临床病理相关性。
