Cho Hee Young, Jung Inkyung, Kim So Jung, Park Yong Won, Kim Young Han, Kwon Ja-Young
Department of Obstetrics and Gynecology, Institute of Women's Life Medical Science, Yonsei University College of Medicine, Yonsei University Health System, Seoul, Korea.
Department of Obstetrics and Gynecology, CHA Bundang Medical Center, CHA University, Seongnam, Korea.
Am J Reprod Immunol. 2017 Sep;78(3). doi: 10.1111/aji.12705. Epub 2017 May 12.
The pathophysiology of preeclampsia (PE) is believed to be associated with a systemic inflammatory response, but few inflammatory markers are currently available to predict PE. Therefore, the aim of this study was to compare the serum delta neutrophil index (DNI) between normal and preeclamptic women.
Sixty-five patients with mild preeclampsia (mPE), 147 patients with severe preeclampsia (sPE), and 163 women with normal pregnancy were included in this study. Maternal laboratory values including DNI were compared among the three groups.
The mean DNI was significantly higher in the sPE group, but there was no significant difference between the normal pregnancy group and mPE. The DNI also showed positive correlation with systolic and diastolic blood pressures, mean arterial pressure, proteinuria during 24 hours, proteinuria in dipstick, and ominous symptoms.
The serum DNI value was increased in women with severe preeclampsia compared to that in those with normal pregnancy or mild preeclampsia. Further studies are needed to evaluate application of the DNI value as a prognostic marker of preeclampsia.
子痫前期（PE）的病理生理学被认为与全身炎症反应有关，但目前几乎没有炎症标志物可用于预测PE。因此，本研究的目的是比较正常孕妇和子痫前期孕妇的血清δ中性粒细胞指数（DNI）。
本研究纳入了65例轻度子痫前期（mPE）患者、147例重度子痫前期（sPE）患者和163例正常妊娠女性。比较三组患者包括DNI在内的母体实验室指标。
sPE组的平均DNI显著更高，但正常妊娠组和mPE组之间无显著差异。DNI还与收缩压和舒张压、平均动脉压、24小时蛋白尿、尿试纸蛋白尿及不良症状呈正相关。
与正常妊娠或轻度子痫前期女性相比，重度子痫前期女性的血清DNI值升高。需要进一步研究以评估DNI值作为子痫前期预后标志物的应用。
