Division of Perinatology, Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkey.
Division of Neonatology, Department of Pediatrics, Ankara Bilkent City Hospital, Ankara, Turkey.
J Obstet Gynaecol. 2022 Aug;42(6):1835-1840. doi: 10.1080/01443615.2022.2040968. Epub 2022 Mar 15.
We aimed to compare the maternal and neonatal systemic inflammatory markers, platelet indices and new indices in biochemical parameters in women with preeclampsia and healthy controls. The secondary aim was to investigate whether there was a relationship between maternal hematological markers and neonatal outcomes. A retrospective case control study was conducted in a tertiary hospital. Maternal demographic and birth characteristics, complete blood count indices, derived neutrophil to lymphocyte ratio (dNLR), Delta neutrophil index (DNI), uric acid-to-creatinine (Cre) ratio and uric acid-to-alanine transaminase ratio, neonatal hematological parameters were compared between the preeclamptic group and control group. The study consisted of 170 cases (84 preeclampsia and 86 control). Neutrophil-to-lymphocyte ratio (NLR), dNLR, blood urea nitrogen (BUN), creatinine (Cre), uric acid, LDH, aspartate transaminase (AST) and alanine aminotransferase (ALT), uric acid-to-Cre ratio and uric acid-to-ALT ratio were higher and statistically significant in the preeclamptic group than in control ones (: 0.000 - BUN, Cre, uric acid, LDH, : 0.001 - AST, : 0.004 - ALT, : 0.000 - uric acid-to-Cre ratio, : 0.009 - uric acid-to-ALT ratio, respectively). NLR and platelet-to-lymphocyte (PLR) ratio were significantly higher in newborns of preeclamptic mothers (: 0.039; : 0.004, respectively). A low-moderate correlation between maternal uric acid-to-Cre ratio and neonatal PLR was detected (r: 0.193; : 0.013). Moreover, moderate negative correlations between maternal PLR (r:-0.231, : 0.002), uric acid (r: 0.332, p:0.000) and adverse neonatal outcomes were found. Uric acid and PLR, which can be easily calculated clinically may predict adverse neonatal outcomes.IMPACT STATEMENT Preeclampsia is known as a significant cause of maternal morbidity and mortality. Haematological indices have been evaluated for the prognosis of many kinds of disease.? This study has focussed on new combined haematological-biochemical indices and its relationship with neonatal outcomes. Both higher NLR, derived NLR, DNI and lower PLR were recorded as useful markers for preeclampsia. Some indices that were calculated by assessing basic and simple blood parameters may help clinicians to predict clinical outcomes of preeclampsia.
我们旨在比较子痫前期患者和健康对照组的母体和新生儿全身炎症标志物、血小板指数和生化参数中的新指标。次要目的是探讨母体血液学标志物与新生儿结局之间是否存在关系。这项回顾性病例对照研究在一家三级医院进行。比较了子痫前期组和对照组的产妇人口统计学和出生特征、全血细胞计数指数、衍生中性粒细胞与淋巴细胞比值（dNLR）、Delta 中性粒细胞指数（DNI）、尿酸与肌酐（Cre）比值和尿酸与丙氨酸氨基转移酶（ALT）比值、新生儿血液学参数。该研究包括 170 例病例（子痫前期 84 例，对照组 86 例）。与对照组相比，子痫前期组的中性粒细胞与淋巴细胞比值（NLR）、dNLR、血尿素氮（BUN）、肌酐（Cre）、尿酸、乳酸脱氢酶（LDH）、天门冬氨酸氨基转移酶（AST）和丙氨酸氨基转移酶（ALT）、尿酸与 Cre 比值和尿酸与 ALT 比值更高且具有统计学意义（：0.000-BUN、Cre、尿酸、LDH、：0.001-AST、：0.004-ALT、：0.000-尿酸与 Cre 比值、：0.009-尿酸与 ALT 比值，分别）。子痫前期母亲新生儿的 NLR 和血小板与淋巴细胞比值（PLR）均显著升高（：0.039；：0.004）。母体尿酸与 Cre 比值与新生儿 PLR 之间存在低中度相关性（r：0.193；：0.013）。此外，还发现母体 PLR（r：-0.231，：0.002）和尿酸（r：0.332，p：0.000）与不良新生儿结局呈中度负相关。尿酸和 PLR 可以在临床上容易计算，可能预测不良新生儿结局。
意义陈述 子痫前期是导致产妇发病率和死亡率的重要原因。已经评估了血液学指标来预测许多疾病的预后。这项研究侧重于新的联合血液学-生化指标及其与新生儿结局的关系。较高的 NLR、衍生 NLR、DNI 和较低的 PLR 均被记录为子痫前期的有用标志物。通过评估基本和简单的血液参数来计算的一些指标可能有助于临床医生预测子痫前期的临床结局。
