Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Italy.
Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Italy.
Biofactors. 2017 Jul 8;43(4):495-506. doi: 10.1002/biof.1363. Epub 2017 May 12.
Citrus fruit and juices represent one of the main sources of compounds with a high potential for health promoting properties. Among these compounds, flavanones (such as hesperetin, naringenin, eriodictyol, isosakuranetin, and their respective glycosides), which occur in quantities ranging from ∼180 to 740 mg/L (depending on the Citrus species and cultivar) are responsible for many biological activities. These compounds support and enhance the body's defenses against oxidative stress and help the organism in the prevention of cardiovascular diseases, atherosclerosis, and cancer. Moreover, among other properties, they also show anti-inflammatory, antiviral, and antimicrobial activities. This review analyzes the biochemistry, pharmacology, and biology of Citrus flavanones, emphasizing the occurrence in Citrus fruits and juices and their bioavailability, structure-function correlations and ability to modulate signal cascades both in vitro and in vivo. © 2017 BioFactors, 43(4):495-506, 2017.
柑橘类水果和果汁是具有高健康促进特性的化合物的主要来源之一。在这些化合物中，类黄酮（如柚皮苷、柚皮苷、圣草酚、异樱花素及其各自的糖苷），其含量范围为 180 至 740mg/L（取决于柑橘属种和品种），负责许多生物活性。这些化合物支持和增强身体对氧化应激的防御能力，并帮助机体预防心血管疾病、动脉粥样硬化和癌症。此外，它们还具有抗炎、抗病毒和抗菌活性。本文综述了柑橘类黄酮的生物化学、药理学和生物学特性，强调了其在柑橘类水果和果汁中的存在及其生物利用度、结构-功能关系以及在体外和体内调节信号级联的能力。
