Sharma Malvika, Akhtar Nadeem, Sambhav Kumar, Shete Ganesh, Bansal Arvind K, Sharma Shyam S
Molecular Neuropharmacology Laboratory, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), S.A.S. Nagar, Mohali, Punjab, India.
Curr Top Med Chem. 2015;15(2):187-95. doi: 10.2174/1568026615666141209163013.
A proper balance between oxidants and antioxidants is necessary in maintaining health and longevity. Alterations in this balance may result in oxidative stress causing functional disorders and diseases. Oxidative stress is considered to play a vital role in the pathogenesis of diabetes and its complications. Flavanones and flavanones-rich botanical extracts have been a subject of great interest for scientific research. Citrus flavanones like naringin and hesperidin exert a variety of biological activities such as anti-oxidant, anti-inflammatory, antihyperglycemic, anti-apoptotic etc. Naringin and hesperidin along with their respective aglycones, naringenin and hesperetin have been shown to attenuate diabetes and its related complications. This review discusses the role of flavanones as a possible emerging treatment for diabetes and its complications along with the possible mechanistic explanations.
氧化剂和抗氧化剂之间保持适当平衡对于维持健康和长寿至关重要。这种平衡的改变可能会导致氧化应激，进而引发功能紊乱和疾病。氧化应激被认为在糖尿病及其并发症的发病机制中起着至关重要的作用。黄烷酮类化合物和富含黄烷酮的植物提取物一直是科学研究的热门课题。柑橘类黄烷酮如柚皮苷和橙皮苷具有多种生物活性，如抗氧化、抗炎、抗高血糖、抗凋亡等。柚皮苷和橙皮苷及其各自的苷元柚皮素和橙皮素已被证明可减轻糖尿病及其相关并发症。本文综述了黄烷酮类化合物作为糖尿病及其并发症可能的新兴治疗方法的作用以及可能的作用机制解释。
