Key Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture), Institute of Animal Husbandry and Veterinary Sciences, Hubei Academy of Agricultural Sciences, Special 1, Nanhuyaoyuan, Hongshan District, Wuhan, 430064, China.
Key Laboratory of Special Pathogens and Biosafety, Wuhan Institute of Virology, Chinese Academy of Science, Wuhan, China.
Poult Sci. 2017 Aug 1;96(8):2630-2640. doi: 10.3382/ps/pex087.
Fowl adenovirus (FAdV) serotype-4 is highly pathogenic for chickens, especially for broilers aged 3 to 5 wk, and it has emerged as one of the foremost causes of economic losses to the poultry industry in the last 30 years. The liver is a major target organ of FAdV-4 infections, and virus-infected chickens usually show symptoms of hydropericardium syndrome. The virus is very contagious, and it is spread both vertically and horizontally. It can be isolated from infected liver homogenates and detected by several laboratory diagnostic methods (including an agar gel immunodiffusion test, indirect immunofluorescence assays, counterimmunoelectrophoresis, enzyme-linked immunosorbent assays, restriction endonuclease analyses, polymerase chain reaction (PCR), real-time PCR, and high-resolution melting-curve analyses). Although inactivated vaccines have been deployed widely to control the disease, attenuated live vaccines and subunit vaccines also have been developed, and they are more attractive vaccine candidates. This article provides a comprehensive review of FAdV-4, including its epidemiology, pathogenesis, diagnostic detection, and vaccine strategies.
禽腺病毒（FAdV）血清型 4 对鸡具有高度致病性，特别是对 3 至 5 周龄的肉鸡，它已成为过去 30 年来家禽业经济损失的主要原因之一。肝脏是 FAdV-4 感染的主要靶器官，感染病毒的鸡通常表现出心包积水综合征的症状。该病毒传染性很强，可通过垂直和水平传播。它可以从受感染的肝匀浆中分离出来，并通过几种实验室诊断方法检测（包括琼脂凝胶免疫扩散试验、间接免疫荧光分析、对流免疫电泳、酶联免疫吸附试验、限制性内切酶分析、聚合酶链反应（PCR）、实时 PCR 和高分辨率熔解曲线分析）。尽管已广泛部署灭活疫苗来控制该疾病，但减毒活疫苗和亚单位疫苗也已开发出来，它们是更具吸引力的疫苗候选物。本文全面综述了 FAdV-4，包括其流行病学、发病机制、诊断检测和疫苗策略。
