Pedinielli Alexandre, Bonnin Sophie, Sanharawi Mohamed El, Mané Valérie, Erginay Ali, Couturier Aude, Tadayoni Ramin
Ophthalmic Surg Lasers Imaging Retina. 2017 May 1;48(5):378-384. doi: 10.3928/23258160-20170428-03.
To compare capillary density (CD) changes assessed by optical coherence tomography angiography (OCTA) during diabetic retinopathy (DR) progression using three previously published methods: binarization, skeletonization, and automated flow density (AFD).
Retrospective study of 98 eyes of 74 patients with diabetes and 18 control eyes imaged using OCTA. The macular CD at each stage of DR was assessed using the three methods and were compared to control eyes.
AFD was the only method that detected differences between controls and severe nonproliferative DR eyes. The three methods showed a significant difference in CD between controls and eyes with proliferative DR, except for the "fovea" area.
Only one of the three methods allowed for the detection of changes from the normal capillary density as early as at the "severe nonproliferative DR" stage due to several refinements from the basic technique. [Ophthalmic Surg Lasers Imaging Retina. 2017;48:378-384.].
使用三种先前发表的方法（二值化、骨架化和自动血流密度（AFD）），比较光学相干断层扫描血管造影（OCTA）评估的糖尿病视网膜病变（DR）进展过程中的毛细血管密度（CD）变化。
对74例糖尿病患者的98只眼和18只对照眼进行回顾性研究，采用OCTA成像。使用这三种方法评估DR各阶段的黄斑CD，并与对照眼进行比较。
AFD是唯一能检测出对照眼与重度非增殖性DR眼之间差异的方法。除“中央凹”区域外，三种方法显示对照眼与增殖性DR眼之间的CD存在显著差异。
由于对基本技术进行了多项改进，三种方法中只有一种能够早在“重度非增殖性DR”阶段就检测到与正常毛细血管密度的变化。[《眼科手术、激光与视网膜成像》。2017；48：378 - 384。]
