UOC Ophthalmology ASL-1 Avezzano-Sulmona-L'Aquila, L'Aquila, Italy.
Department of Medicine and Science of Ageing, Ophthalmology Clinic, University G. d'Annunzio Chieti-Pescara, Chieti, Italy.
PLoS One. 2020 Dec 1;15(12):e0243074. doi: 10.1371/journal.pone.0243074. eCollection 2020.
To assess the different impact of two enface OCTA image simultaneously acquired by means of a new prototype of Spectral-Domain Optical Coherence Tomography Angiography (SD-OCTA) on quantitative retinal vascular metrics.
In this prospective observational cross-sectional study 28 healthy subjects were enrolled. Macular (3x3 mm) OCTA images were acquired for all participants using Solix Fullrange OCT (Optovue Inc, Freemont CA, USA). The main outcome measurements were: Perfusion density (PD), vessel length density (VLD), and vessel diameter index (VDI) of both superficial capillary plexus (SCP) and deep capillary plexus (DCP), and choriocapillaris (CC) total flow-deficits area. Quantitative retinal vascular metrics were measured on binarized and skeletonized OCTA images by comparing not averaged and fast automated multiple averaged en face OCTA images.
In both SCP and DCP, PD significantly increased (p = 0,005 and p = 0,030, respectively), and VLD significantly decreased (p<0,001 and p = 0,004, respectively), and VDI increased (p<0,001 and p = 0,068, respectively), and total CC flow deficits area significantly decreased (p<0,001) by averaging multiple OCTA images.
In this study, we found a significant difference of quantitative retinal metrics by comparing two different image acquisition modes using a novel and fully automated averaging OCTA system in young healthy subjects.
评估新型光谱域光相干断层扫描血管造影（SD-OCTA）同时获取的两种对视功能有不同影响的 OCTA 图像对视功能定量血管参数的影响。
本前瞻性观察性横断面研究纳入 28 名健康受试者。所有参与者均使用 Solix Fullrange OCT（Optovue Inc，弗里蒙特，加利福尼亚州，美国）采集黄斑（3x3mm）OCTA 图像。主要观察指标为：浅层毛细血管丛（SCP）和深层毛细血管丛（DCP）的灌注密度（PD）、血管长度密度（VLD）和血管直径指数（VDI），以及脉络膜毛细血管（CC）总血流不足面积。通过比较非平均和快速自动多次平均的视功能 OCTA 图像，在二值化和骨架化 OCTA 图像上测量定量视网膜血管参数。
在 SCP 和 DCP 中，PD 均显著增加（p=0.005 和 p=0.030），VLD 显著降低（p<0.001 和 p=0.004），VDI 增加（p<0.001 和 p=0.068），总 CC 血流不足面积显著减少（p<0.001），多次 OCTA 图像平均化后。
在这项研究中，我们发现使用新型全自动平均 OCTA 系统比较两种不同图像采集模式时，年轻健康受试者的定量视网膜参数存在显著差异。
