钙蛋白酶合成抑制剂对大鼠红细胞膜蛋白质水解作用的抑制
Inhibition of the proteolysis of rat erythrocyte membrane proteins by a synthetic inhibitor of calpain.
作者信息
Mehdi S, Angelastro M R, Wiseman J S, Bey P
机构信息
Merrell Dow Research Institute, Cincinnati, OH 45215.
出版信息
Biochem Biophys Res Commun. 1988 Dec 30;157(3):1117-23. doi: 10.1016/s0006-291x(88)80989-6.
PMID:2849930
Abstract
A synthetic inhibitor of calpain protects rat erythrocyte membrane-associated cytoskeletal proteins from proteolytic degradation (IC50 = 1 microM) which occurs when the cells are rendered permeable to Ca++. Leupeptin, a naturally occurring inhibitor of the enzyme, does not afford any protection at concentrations up to 100 microM.
摘要
钙蛋白酶的一种合成抑制剂可保护大鼠红细胞膜相关细胞骨架蛋白免受蛋白水解降解（IC50 = 1 microM），这种降解在细胞对Ca++通透时发生。亮抑蛋白酶肽是该酶的一种天然抑制剂，在浓度高达100 microM时没有提供任何保护作用。
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