放射性碘治疗甲状腺乳头状癌后发生的黏液表皮样癌：独特表现及可能的病因关联

Mucoepidermoid carcinoma post-radioactive iodine treatment of papillary thyroid carcinoma: unique presentation and putative etiologic association.

作者信息

Saluja Karan, Butler Randall T, Pytynia Kristen B, Zhao Bihong, Karni Ron J, Weber Randal S, El-Naggar Adel K

机构信息

Department of Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Department of Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA.

出版信息

Hum Pathol. 2017 Oct;68:189-192. doi: 10.1016/j.humpath.2017.04.019. Epub 2017 May 10.

DOI:10.1016/j.humpath.2017.04.019

PMID:28499545

Abstract

We report the development of mucoepidermoid carcinomas of the parotid gland in 2 adult patients after a relatively short duration of radioactive iodine (RAI) treatment of papillary thyroid carcinoma. Both instances, together with those previously reported, underscore the selective nature of the mucoepidermoid carcinoma phenotype development in patients with papillary thyroid carcinoma as a consequence of RAI treatment. Efforts to alleviate salivary pathophysiologic damage by RAI in these patients are warranted.

摘要

我们报告了2例成年患者在接受相对较短疗程的放射性碘（RAI）治疗甲状腺乳头状癌后发生腮腺黏液表皮样癌的情况。这两例病例以及先前报道的病例均强调，放射性碘治疗甲状腺乳头状癌的患者发生黏液表皮样癌表型具有选择性。因此，有必要努力减轻这些患者因放射性碘治疗导致的唾液生理病理损伤。