肺癌中HE4的表达：一项荟萃分析
HE4 expression in lung cancer, a meta-analysis.
作者信息
Zhong Hai, Qian Yingying, Fang Surong, Yang Linfei, Li Lingzhi, Gu Wei
机构信息
Department of Respiration, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, Jiangsu 210006, People's Republic of China.
Department of Respiration, Nanjing First Hospital, Nanjing Medical University, 68 Changle Road, Nanjing, Jiangsu 210006, People's Republic of China.
出版信息
Clin Chim Acta. 2017 Jul;470:109-114. doi: 10.1016/j.cca.2017.05.007. Epub 2017 May 9.
BACKGROUND
The prognostic role of Human epididymis protein 4 (HE4) expression in lung cancer remains controversial. We performed this meta-analysis to assess the prognostic value of HE4 expression in lung cancer.
METHODS
A systematic literature search was conducted to identify eligible studies in PubMed, Embase and Wanfang databases. The pooled hazard ratios (HRs) and their 95% confidence intervals (CIs) were used to assess the relationship.
RESULTS
A total of 1412 patients from 8 studies were included in this meta-analysis. The results of univariate analysis (HR=1.73, 95% CI: 1.19-2.52, P=0.004) and multivariate analysis (HR=2.49, 95% CI: 1.89-3.28, P<0.001) demonstrated that high HE4 expression in lung cancer patients was correlated with poor overall survival (OS). We observed through further stratified analysis of the results of the univariate analysis that high HE4 expression was associated with worse OS in Asian lung cancer patients (HR=2.48, 95% CI: 1.88-3.26, P<0.001). However, there was no significant association between high HE4 expression and poor OS in Caucasian patients (HR=1.12, 95% CI: 0.80-1.55, P=0.513).
CONCLUSION
High serum HE4 level was a marker of poor prognosis in lung cancer patients, particularly in Asian patients with lung cancer.
背景
人附睾蛋白4（HE4）表达在肺癌中的预后作用仍存在争议。我们进行了这项荟萃分析以评估HE4表达在肺癌中的预后价值。
方法
进行系统的文献检索，以在PubMed、Embase和万方数据库中识别符合条件的研究。汇总风险比（HR）及其95%置信区间（CI）用于评估这种关系。
结果
本荟萃分析共纳入了来自8项研究的1412例患者。单因素分析结果（HR=1.73，95%CI：1.19-2.52，P=0.004）和多因素分析结果（HR=2.49，95%CI：1.89-3.28，P<0.001）表明，肺癌患者中HE4高表达与总体生存期（OS）较差相关。我们通过对单因素分析结果进行进一步分层分析观察到，亚洲肺癌患者中HE4高表达与较差的OS相关（HR=2.48，95%CI：1.88-3.26，P<0.001）。然而，在白种人患者中，HE4高表达与较差的OS之间无显著关联（HR=1.12，95%CI：0.80-1.55，P=0.513）。
结论
血清HE4水平高是肺癌患者预后不良的标志物，尤其是在亚洲肺癌患者中。
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