Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic.
Central European Institute of Technology (CEITEC), Masaryk University, Brno, Czech Republic; Department of Psychiatry, Medical Faculty, Masaryk University, Brno, Czech Republic.
Int J Psychophysiol. 2017 Jul;117:119-125. doi: 10.1016/j.ijpsycho.2017.05.004. Epub 2017 May 10.
Comparison between the intended and performed motor action can be expected to occur in the final epoch of a voluntary movement. In search for electrophysiological correlates of this mental process the purpose of the current study was to identify intracerebral sites activated in final epoch of self-paced voluntary movement. Intracerebral EEG was recorded from 235 brain regions of 42 epileptic patients who performed self-paced voluntary movement task. Evoked potentials starting at 0 to 243ms after the peak of averaged, rectified electromyogram were identified in 21 regions of 13 subjects. The mean amplitude value of these late movement potentials (LMP) was 56.4±27.5μV. LMPs were observed in remote regions of mesiotemporal structures, cingulate, frontal, temporal, parietal, and occipital cortices. Closely before the LMP onset, a significant increase of phase synchronization was observed in all EEG record pairs in 9 of 10 examined subjects; p<0.001, Mann-Whitney U test. In conclusion, mesiotemporal structures, cingulate, frontal, temporal, parietal, and occipital cortices seem to represent integral functionally linked parts of network activated in final epoch of self-paced voluntary movement. Activation of this large-scale neuronal network was suggested to reflect a comparison process between the intended and actually performed motor action. Our results contribute to better understanding of neural mechanisms underlying goal-directed behavior crucial for creation of agentive experience.
可以预期，在自愿运动的最后一个时期，会发生预期和执行的运动动作之间的比较。为了寻找这个心理过程的电生理相关性，本研究的目的是确定在自我调节自愿运动的最后一个时期激活的颅内部位。从 42 名癫痫患者的 235 个脑区记录了颅内 EEG，这些患者执行了自我调节的自愿运动任务。在 13 名受试者的 21 个区域中，确定了从平均、整流肌电图峰值后 0 到 243ms 开始的诱发电位。这些晚期运动电位（LMP）的平均幅度值为 56.4±27.5μV。LMPs 出现在中颞叶结构、扣带回、额、颞、顶和枕叶皮层的远程区域。在 LMP 出现之前，在所有 EEG 记录对中，在 10 个检查对象中的 9 个中观察到相位同步显著增加；p<0.001，Mann-Whitney U 检验。总之，中颞叶结构、扣带回、额、颞、顶和枕叶皮层似乎代表了在自我调节自愿运动的最后一个时期激活的网络中整合的功能连接部分。这个大规模神经元网络的激活被认为反映了预期和实际执行的运动动作之间的比较过程。我们的结果有助于更好地理解目标导向行为的神经机制，这对于创造代理体验至关重要。
