Damborská Alena, Roman Robert, Brázdil Milan, Rektor Ivan, Kukleta Miloslav
CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic; Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic; Department of Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Clin Neurophysiol. 2016 Feb;127(2):1297-1306. doi: 10.1016/j.clinph.2015.08.014. Epub 2015 Sep 4.
To identify intracerebral sites activated after correct motor response during cognitive task and to assess associations of this activity with mental processes.
Intracerebral EEG was recorded from 205 sites of frontal, temporal and parietal lobes in 18 epileptic patients, who responded by button pressing together with mental counting to target stimuli in visual oddball task.
Post-movement event-related potentials (ERPs) with mean latency 295 ± 184 ms after movement were found in all subjects in 64% of sites investigated. Generators were consistently observed in mesiotemporal structures, anterior midcingulate, prefrontal, and temporal cortices. Task-variant nonspecific and target specific post-movement ERPs were identified, displaying no significant differences in distribution among generating structures. Both after correct and incorrect performances the post-performance ERPs were observed in frontal and temporal cortices with latency sensitive to error commission in several frontal regions.
Mesiotemporal structures and regions in anterior midcingulate, prefrontal and temporal cortices seem to represent integral parts of network activated after correct motor response in visual oddball task with mental counting. Our results imply equivalent involvement of these structures in task-variant nonspecific and target specific processes, and suggest existence of common nodes for correct and incorrect responses.
Our results contribute to better understanding of neural mechanisms underlying goal-directed behavior.
确定在认知任务期间正确运动反应后激活的脑内位点，并评估该活动与心理过程的关联。
对18例癫痫患者额叶、颞叶和顶叶的205个位点进行脑内脑电图记录，这些患者在视觉oddball任务中通过按键和心理计数对目标刺激做出反应。
在所有受试者中，64%的研究位点在运动后出现平均潜伏期为295±184 ms的运动后事件相关电位（ERP）。在颞叶内侧结构、前扣带回中部、前额叶和颞叶皮质中持续观察到发生器。识别出任务变体非特异性和目标特异性运动后ERP，其在产生结构中的分布无显著差异。在正确和错误表现后，前额叶和颞叶皮质均观察到表现后ERP，其潜伏期在几个前额叶区域对错误产生敏感。
颞叶内侧结构以及前扣带回中部、前额叶和颞叶皮质区域似乎代表了在视觉oddball任务中进行心理计数时正确运动反应后激活的网络的组成部分。我们的结果表明这些结构在任务变体非特异性和目标特异性过程中同等参与，并提示存在正确和错误反应的共同节点。
我们的结果有助于更好地理解目标导向行为背后的神经机制。
