Shchelkovnikov S A, Starshinova L A, Garnovskaia M N, Artem'ev N O, Etingof R N
Biull Eksp Biol Med. 1988 Dec;106(12):648-50.
The presence of the peptide activator of cyclic nucleotide phosphodiesterase, which has been discovered previously in rat and calf myometrium, was studied in different rat tissues. The peptide was shown to present only in muscle tissues, except for intestinal tissue. In physiological experiments the peptide stimulated the contraction of rat uterine smooth muscle and diaphragmatic muscle. Phosphodiesterase inhibitors reduced this effect of the peptide. It is suggested that the effects of peptide are related to the changes in cyclic nucleotide levels in consequence of phosphodiesterase activation. Peptide did not change the activity of uterine adenylate cyclase.
此前在大鼠和小牛子宫肌层中发现的环核苷酸磷酸二酯酶的肽激活剂，在不同的大鼠组织中进行了研究。结果表明，该肽仅存在于肌肉组织中，肠道组织除外。在生理学实验中，该肽刺激大鼠子宫平滑肌和膈肌收缩。磷酸二酯酶抑制剂可降低该肽的这种作用。提示该肽的作用与磷酸二酯酶激活导致的环核苷酸水平变化有关。该肽不会改变子宫腺苷酸环化酶的活性。
