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体内内皮舒张因子活性影响血小板功能。

In vivo EDRF activity influences platelet function.

作者信息

Hogan J C, Lewis M J, Henderson A H

机构信息

Department of Pharmacology and Thereapeutics, University of Wales College of Medicine, Heath Park, Cardiff.

出版信息

Br J Pharmacol. 1988 Aug;94(4):1020-2. doi: 10.1111/j.1476-5381.1988.tb11616.x.

DOI:10.1111/j.1476-5381.1988.tb11616.x
PMID:2850053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1854093/
Abstract

The administration of carbachol to rabbits to stimulate the release of endothelium derived relaxing factor (EDRF) results in inhibition of platelet aggregation and elevation of platelet cyclic GMP content. These effects are reversed by simultaneous administration of the EDRF inhibitors methylene blue or haemoglobin. The data provide the first direct biochemical evidence of in vivo EDRF activity.

摘要

给兔子注射卡巴胆碱以刺激内皮衍生舒张因子（EDRF）释放，结果会抑制血小板聚集并提高血小板环鸟苷酸（cGMP）含量。同时给予EDRF抑制剂亚甲蓝或血红蛋白可逆转这些效应。这些数据提供了体内EDRF活性的首个直接生化证据。

相似文献

1
In vivo EDRF activity influences platelet function.体内内皮舒张因子活性影响血小板功能。
Br J Pharmacol. 1988 Aug;94(4):1020-2. doi: 10.1111/j.1476-5381.1988.tb11616.x.
2
Human endothelial cells inhibit platelet aggregation by separately stimulating platelet cyclic AMP and cyclic GMP.人类内皮细胞通过分别刺激血小板环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）来抑制血小板聚集。
Eur J Pharmacol. 1989 May 2;164(1):103-10. doi: 10.1016/0014-2999(89)90236-7.
3
N-acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor.N-乙酰半胱氨酸可增强内皮源性舒张因子对血小板的抑制作用。
Circ Res. 1989 Sep;65(3):789-95. doi: 10.1161/01.res.65.3.789.
4
Platelet inhibition by endothelium-derived relaxing factor from the rabbit perfused aorta.兔灌注主动脉中内皮衍生舒张因子对血小板的抑制作用。
Br J Pharmacol. 1988 Dec;95(4):1308-14. doi: 10.1111/j.1476-5381.1988.tb11769.x.
5
Vascular smooth muscle sensitivity to endothelium-derived relaxing factor is different in different arteries.血管平滑肌对内皮源性舒张因子的敏感性在不同动脉中有所不同。
Br J Pharmacol. 1988 Oct;95(2):630-6. doi: 10.1111/j.1476-5381.1988.tb11685.x.
6
Antiplatelet effects of endothelium-derived relaxing factor and nitric oxide donors.内皮源性舒张因子和一氧化氮供体的抗血小板作用。
Eur Heart J. 1991 Nov;12 Suppl E:12-5. doi: 10.1093/eurheartj/12.suppl_e.12.
7
Atrial natriuretic peptide inhibits the release of endothelium-derived relaxing factor from blood vessels of the rabbit.心房利钠肽抑制兔血管内皮源性舒张因子的释放。
Eur J Pharmacol. 1989 Jun 8;165(1):129-34. doi: 10.1016/0014-2999(89)90778-4.
8
Endothelium-derived relaxant factor inhibits platelet activation.内皮衍生舒张因子抑制血小板活化。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Nov;336(5):566-71. doi: 10.1007/BF00169315.
9
Endothelium-derived relaxing factor modulates platelet aggregation in an in vivo model of recurrent platelet activation.内皮衍生舒张因子在复发性血小板激活的体内模型中调节血小板聚集。
Circ Res. 1992 Dec;71(6):1447-56. doi: 10.1161/01.res.71.6.1447.
10
Cyclic GMP release and vasodilatation induced by EDRF and atrial natriuretic factor in the isolated perfused kidney of the rat.大鼠离体灌注肾中由内皮舒张因子和心房利钠因子诱导的环鸟苷酸释放及血管舒张
Br J Pharmacol. 1990 Feb;99(2):364-8. doi: 10.1111/j.1476-5381.1990.tb14709.x.

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St Cyres lecture. Endothelium in control.圣赛尔斯讲座。内皮细胞的调控
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本文引用的文献

1
The nature of endothelium-derived vascular relaxant factor.内皮源性血管舒张因子的本质。
Nature. 1984;308(5960):645-7. doi: 10.1038/308645a0.
2
Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.激动剂诱导的大鼠胸主动脉内皮依赖性舒张可能通过环磷酸鸟苷（cGMP）介导。
Circ Res. 1983 Mar;52(3):352-7. doi: 10.1161/01.res.52.3.352.
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The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine.内皮细胞在乙酰胆碱介导的动脉平滑肌舒张中所起的不可或缺的作用。
Nature. 1980 Nov 27;288(5789):373-6. doi: 10.1038/288373a0.
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Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.有机硝酸盐、亚硝酸盐、硝普钠和一氧化氮引起血管平滑肌舒张的机制：关于S-亚硝基硫醇作为活性中间体参与其中的证据。
J Pharmacol Exp Ther. 1981 Sep;218(3):739-49.
5
Release and properties of endothelium-derived relaxing factor (EDRF) from endothelial cells in culture.培养的内皮细胞中内皮源性舒张因子（EDRF）的释放及特性
J Cell Physiol. 1985 Jun;123(3):310-20. doi: 10.1002/jcp.1041230304.
6
Endothelium-derived relaxing factor inhibits in vitro platelet aggregation.内皮衍生舒张因子抑制体外血小板聚集。
Br J Pharmacol. 1987 Apr;90(4):687-92. doi: 10.1111/j.1476-5381.1987.tb11221.x.
7
Haptoglobin-haemoglobin complex in human plasma inhibits endothelium dependent relaxation: evidence that endothelium derived relaxing factor acts as a local autocoid.人血浆中的触珠蛋白-血红蛋白复合物抑制内皮依赖性舒张：内皮源性舒张因子作为局部自分泌物质的证据。
Cardiovasc Res. 1986 Aug;20(8):549-56. doi: 10.1093/cvr/20.8.549.
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The role of endothelium in the control of vascular tone.内皮细胞在血管张力控制中的作用。
Basic Res Cardiol. 1985 Sep-Oct;80(5):475-90. doi: 10.1007/BF01907912.
9
Selective blockade of endothelium-dependent and glyceryl trinitrate-induced relaxation by hemoglobin and by methylene blue in the rabbit aorta.血红蛋白和亚甲蓝对兔主动脉内皮依赖性舒张及硝酸甘油诱导舒张的选择性阻断作用
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