内皮衍生舒张因子抑制体外血小板聚集。
Endothelium-derived relaxing factor inhibits in vitro platelet aggregation.
作者信息
Furlong B, Henderson A H, Lewis M J, Smith J A
出版信息
Br J Pharmacol. 1987 Apr;90(4):687-92. doi: 10.1111/j.1476-5381.1987.tb11221.x.
Abstract
We studied the effects of endothelium-derived relaxing factor (EDRF), bovine retractor penis muscle inhibitory factor and sodium nitroprusside, three stimulants of guanylate cyclase, on the in vitro aggregation of washed human platelets. Platelet aggregation induced either by collagen or by the thromboxane A2 analogue U46619 was inhibited by all three agents. The anti-aggregatory effect of each agent was inhibited by haemoglobin. The anti-aggregatory effect of EDRF was potentiated by superoxide dismutase. These findings are discussed in relation to a potential role for EDRF in haemostasis.
摘要
我们研究了内皮源性舒张因子（EDRF）、牛阴茎退缩肌抑制因子和硝普钠这三种鸟苷酸环化酶刺激剂对洗涤过的人血小板体外聚集的影响。胶原或血栓素A2类似物U46619诱导的血小板聚集均受到这三种药物的抑制。每种药物的抗聚集作用均受到血红蛋白的抑制。超氧化物歧化酶可增强EDRF的抗聚集作用。结合EDRF在止血中的潜在作用对这些发现进行了讨论。
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