牛磺酸调节注射了来自小鼠大脑信使核糖核酸的非洲爪蟾卵母细胞中的甘氨酸反应。

Taurine modulates glycine response in Xenopus oocytes injected with messenger RNA from mouse brain.

作者信息

Horikoshi T, Asanuma A, Yanagisawa K, Goto S

机构信息

Department of Physiology, School of Dental Medicine, Tsurumi University, Yokohama, Japan.

出版信息

Brain Res. 1988 Nov;464(3):243-6. doi: 10.1016/0169-328x(88)90030-7.

DOI:10.1016/0169-328x(88)90030-7

PMID:2850085

Abstract

The modulatory action of taurine on the glycine response was investigated in Xenopus oocytes injected with messenger RNA from mouse brainstem under voltage-clamped condition. Taurine competitively inhibited the glycine response in a dose-dependent manner. This inhibition was insensitive to bicuculline and intracellularly injected EGTA. The results suggest that taurine could directly modulate glycinergic neurotransmission in the central nervous system.

摘要

在电压钳制条件下，对注射了来自小鼠脑干信使核糖核酸的非洲爪蟾卵母细胞研究了牛磺酸对甘氨酸反应的调节作用。牛磺酸以剂量依赖性方式竞争性抑制甘氨酸反应。这种抑制作用对荷包牡丹碱和细胞内注射的乙二醇双四乙酸不敏感。结果表明，牛磺酸可直接调节中枢神经系统中的甘氨酸能神经传递。