Lapa Paula, Saraiva Tiago, Silva Rodolfo, Marques Margarida, Costa Gracinda, Lima João Pedroso
Serviço de Medicina Nuclear. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.
Serviço de Medicina Nuclear. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal; Instituto de Ciências Nucleares Aplicadas à Saúde. Universidade de Coimbra. Coimbra. Portugal.
Acta Med Port. 2017 Jan 31;30(1):53-60. doi: 10.20344/amp.7818.
The 18F-NaF positron emission tomography/computed tomography is being considered as an excellent imaging modality for bone metastases detection. This ability was compared with other imaging techniques.
We retrospectively evaluated 114 patients who underwent 18F-NaF positron emission tomography/ computed tomography. Of these, 49 patients also had bone scintigraphy, 61 18F-FDG positron emission tomography/computed tomography and 10 18F-FCH positron emission tomography/computed tomography. We identified the technique that detected the largest number of bone metastases. For the detection of skeletal metastases with the 18F-NaF positron emission tomography/computed tomography study, the contribution of the positron emission tomography component was compared with the contribution of the computed tomography component. Cases in which 18F-NaF positron emission tomography/computed tomography and bone scintigraphy required further additional tests for diagnosis clarification were registered.
The 18F-NaF positron emission tomography/computed tomography was superior to bone scintigraphy in 49% of the patients (p < 0.001); it was superior to 18F-FDG positron emission tomography/computed tomography in 59% of the patients (p < 0.001) and it was superior to 18F-FCH positron emission tomography/computed tomography in 40% of the patients (p < 0.001). None of the compared imaging techniques were superior to 18F-NaF positron emission tomography/computed tomography. The positron emission tomography component was superior to computed tomography in 35% of the cases (p < 0.001). Further investigation was suggested in only 3.5% of patients who underwent 18F-NaF positron emission tomography/computed tomography (45% for bone scintigraphy) (p < 0.001).
As with other authors, our experience also confirms that 18F-NaF positron emission tomography/computed tomography is an excellent imaging modality for the detection of bone metastases, detecting lesions in more patients and more lesions per patient.
The 18F-NaF positron emission tomography/computed tomography showed a superior ability for the detection of bone metastases when compared with bone scintigraphy, 18F-FDG positron emission tomography/computed tomography and 18F-FCH positron emission tomography/computed tomography.
18F-氟化钠正电子发射断层扫描/计算机断层扫描被认为是检测骨转移的一种优秀成像方式。将这种能力与其他成像技术进行了比较。
我们回顾性评估了114例行18F-氟化钠正电子发射断层扫描/计算机断层扫描的患者。其中，49例患者还进行了骨闪烁显像，61例进行了18F-氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描，10例进行了18F-氟代胆碱正电子发射断层扫描/计算机断层扫描。我们确定了检测到骨转移数量最多的技术。对于通过18F-氟化钠正电子发射断层扫描/计算机断层扫描研究检测骨转移，将正电子发射断层扫描部分的贡献与计算机断层扫描部分的贡献进行了比较。记录了18F-氟化钠正电子发射断层扫描/计算机断层扫描和骨闪烁显像需要进一步额外检查以明确诊断的病例。
在49%的患者中，18F-氟化钠正电子发射断层扫描/计算机断层扫描优于骨闪烁显像（p<0.001）；在59%的患者中，它优于18F-氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（p<0.001），在40%的患者中，它优于18F-氟代胆碱正电子发射断层扫描/计算机断层扫描（p<0.001）。所比较的成像技术均不优于18F-氟化钠正电子发射断层扫描/计算机断层扫描。在35%的病例中，正电子发射断层扫描部分优于计算机断层扫描（p<0.001）。在接受18F-氟化钠正电子发射断层扫描/计算机断层扫描的患者中，仅3.5%的患者建议进一步检查（骨闪烁显像为45%）（p<0.001）。
与其他作者一样，我们的经验也证实，18F-氟化钠正电子发射断层扫描/计算机断层扫描是检测骨转移的一种优秀成像方式，能检测出更多患者的病变以及每位患者更多的病变。
与骨闪烁显像、18F-氟代脱氧葡萄糖正电子发射断层扫描/计算机断层扫描和18F-氟代胆碱正电子发射断层扫描/计算机断层扫描相比，18F-氟化钠正电子发射断层扫描/计算机断层扫描在检测骨转移方面显示出更强的能力。
