Dadgar Habibollah, Norouzbeigi Nasim, Jokar Narges, Zareizadeh Jafar, Gholamrezanezhad Ali, Ahmadzadehfar Hojjat, Abbaszadeh Moloud, Assadi Majid
Cancer Research Center, Imam Reza International University, Razavi Hospital, Mashhad, Iran.
Department of Molecular Imaging and Radionuclide Therapy (MIRT), The Persian Gulf Nuclear Medicine Research Center, School of Medicine, Bushehr University of Medical Sciences, Bushehr Medical University Hospital, Bushehr, Iran.
World J Nucl Med. 2022 Apr 30;21(1):1-8. doi: 10.1055/s-0042-1748154. eCollection 2022 Mar.
Bone is a common metastasis site in several malignancies, most importantly prostate and breast cancers. Given the significance of the early and accurate diagnosis of bone metastases for preliminary staging, treatment planning and monitoring, restaging, and survival prediction in patients with malignancy, it is critical to compare and contrast the strengths and weaknesses of imaging modalities. Although technetium-99m-labeled diphosphonates [ Tc-MDP] scintigraphy has been used for assessing skeletal involvement, there is a renewed interest in fluorine-18-labeled sodium fluoride [ F-NaF] bone imaging with positron emission tomography or positron emission tomography/computed tomography, since this approach provides essential advantages in bone metastases evaluation. This review study aimed to discuss the basic and technical aspects of F-NaF imaging and its mechanism of action, and compare this modality with the Tc-MDP bone scan and 18F-fluorodeoxyglucose using current evidence from the pertinent literature and case examples of the center in the study.
骨是多种恶性肿瘤常见的转移部位，其中最重要的是前列腺癌和乳腺癌。鉴于早期准确诊断骨转移对于恶性肿瘤患者的初步分期、治疗规划与监测、再分期以及生存预测具有重要意义，比较和对比各种成像方式的优缺点至关重要。尽管锝-99m标记的二膦酸盐[Tc-MDP]闪烁扫描已用于评估骨骼受累情况，但正电子发射断层扫描或正电子发射断层扫描/计算机断层扫描的氟-18标记氟化钠[F-NaF]骨成像重新引起了人们的关注，因为这种方法在骨转移评估中具有重要优势。本综述研究旨在讨论F-NaF成像的基本和技术方面及其作用机制，并利用相关文献的现有证据以及该研究中心的病例实例，将这种成像方式与Tc-MDP骨扫描和18F-氟脱氧葡萄糖进行比较。
