Zhang Chao, Powell Sarah Ellen, Betel Doron, Shah Manish A
Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY 10021, USA; Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
Division of Hematology and Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
Hematol Oncol Clin North Am. 2017 Jun;31(3):389-408. doi: 10.1016/j.hoc.2017.01.002. Epub 2017 Mar 22.
Gastric malignancies are a leading cause of cancer-related death worldwide. At least 2 microbial species are currently linked to carcinogenesis and the development of cancer within the human stomach. These include the bacterium Helicobacter pylori and the Epstein-Barr virus. In recent years, there has been increasing evidence that within the human gastrointestinal tract it is not only pathogenic microbes that impact human health but also the corresponding autochthonous microbial communities. This article reviews the gastrointestinal microbiome as it relates primarily to mechanisms of disease and carcinogenesis within the upper gastrointestinal tract.
胃癌是全球癌症相关死亡的主要原因。目前至少有2种微生物与人类胃部的致癌作用和癌症发展有关。其中包括幽门螺杆菌和爱泼斯坦-巴尔病毒。近年来，越来越多的证据表明，在人类胃肠道内，不仅致病微生物会影响人类健康，相应的本土微生物群落也会产生影响。本文主要综述了与上消化道疾病和致癌机制相关的胃肠道微生物组。
