使用新型高原高压氧舱缓解高原缺氧：兔类与人体研究。

Using a new plateau hyperbaric chamber to alleviate high altitude hypoxia: Rabbit and human studies.

作者信息

Sun Liang, Ding Meng-Jiang, Cai Tian-Cai, Fan Hao-Jun, Gao Hong-Mei, Zhang Jian-Peng

机构信息

Medical College of Chinese PLA, Chinese PLA General Hospital, 28#, Fu-Xing Road, Haidian District, Beijing 100853, China; Department of Respiratory and Critical Care Medicine of Ping Jin Hospital, Affiliated Hospital of Logistic University of Chinese People's Armed Police Force, China.

Tianjin Municipal Corps Hospital of Chinese People's Armed Police Forces, China.

出版信息

Am J Emerg Med. 2017 Oct;35(10):1536-1541. doi: 10.1016/j.ajem.2017.04.034. Epub 2017 Apr 19.

DOI:10.1016/j.ajem.2017.04.034

PMID:28501324

Abstract

OBJECTIVES

To validate the effects of the new plateau hyperbaric chamber on alleviating high altitude hypoxia on Mount Kun Lun.

METHODS

A prospective, controlled study of rabbits and adult volunteers was conducted at altitudes of 355, 2880 and 4532m. We obtained arterial blood samples from rabbits and volunteers before and after hyperbaric treatment. The respiratory rate, heart rate, and blood pressure (BP) of adult volunteers were monitored during hyperbaric treatment.

RESULTS

The mean PaO levels of experimental group rabbits and volunteers increased significantly after 60min of hyperbaric treatment at 350, 2880 and 4532m. The mean PaCO and pH levels of rabbits were not significant different before and after hyperbaric treatment at each altitude. The mean PaCO and pH levels were not significant different at 355m in the human study. However, at 2880 and 4532m, pH fell with increasing PaCO levels in humans before and after hyperbaric treatment.

CONCLUSIONS

The new multiplace plateau hyperbaric chamber may be used to alleviate plateau hypoxia by increasing patient PaO. However, its value in treating AMS must be confirmed in field conditions.

摘要

目的

验证新型高原高压氧舱对缓解昆仑山脉高原缺氧的效果。

方法

在海拔355米、2880米和4532米处对兔子和成年志愿者进行前瞻性对照研究。在高压治疗前后采集兔子和志愿者的动脉血样本。在高压治疗期间监测成年志愿者的呼吸频率、心率和血压（BP）。

结果

在海拔350米、2880米和4532米处进行60分钟高压治疗后，实验组兔子和志愿者的平均动脉血氧分压（PaO）水平显著升高。在各海拔高度，兔子高压治疗前后的平均动脉血二氧化碳分压（PaCO）和pH值水平无显著差异。在人体研究中，海拔355米处的平均动脉血二氧化碳分压和pH值水平无显著差异。然而，在海拔2880米和4532米处，人体高压治疗前后pH值随动脉血二氧化碳分压水平升高而下降。