Kasic J F, Yaron M, Nicholas R A, Lickteig J A, Roach R
Department of Chemical Engineering, University of Colorado, Boulder 80309-0424.
Ann Emerg Med. 1991 Oct;20(10):1109-12. doi: 10.1016/s0196-0644(05)81385-x.
To compare the benefits of simulated descent in a hyperbaric chamber with those of supplementary oxygen for the treatment of acute mountain sickness.
A prospective study.
The Snake River Health Clinic in Keystone, Colorado, which has an altitude of 2,850 m (9,300 ft).
Twenty-four patients who presented with acute mountain sickness.
A simulated descent of 1,432 m (4,600 ft) was attained by placing the patients in a fabric hyperbaric chamber and pressurizing the chamber to 120 mm Hg (2.3 PSI) above ambient pressure. Patients were randomly assigned to either the hyperbaric treatment or treatment with 4 L of oxygen given by facemask; both treatments lasted for two hours.
Mean arterial oxygen saturation (SaO2) increased 7% (84 +/- 2% to 91 +/- 1%) with pressurization and 14% (83 +/- 4% to 96 +/- 1%) with oxygen during treatment over pretreatment levels. Symptoms of acute mountain sickness decreased as rapidly with pressurization as with oxygen treatment, despite significantly higher SaO2 in the oxygen-treated group during treatment. Symptomatic improvement was retained in both groups at least one hour after treatment.
Simulated descent in a fabric hyperbaric chamber is as effective as oxygen therapy for the immediate relief of acute mountain sickness.
比较高压舱内模拟下降与补充氧气治疗急性高原病的益处。
前瞻性研究。
科罗拉多州基斯通的蛇河健康诊所，海拔2850米（9300英尺）。
24例急性高原病患者。
将患者置于织物高压舱内，使舱内压力高于环境压力120毫米汞柱（2.3磅力/平方英寸），实现1432米（4600英尺）的模拟下降。患者被随机分配接受高压治疗或面罩吸氧4升治疗；两种治疗均持续两小时。
治疗期间，与治疗前水平相比，加压时平均动脉血氧饱和度（SaO2）增加7%（从84±2%增至91±1%），吸氧时增加14%（从83±4%增至96±1%）。尽管治疗期间吸氧组的SaO2显著更高，但加压时急性高原病症状缓解速度与吸氧治疗相同。两组治疗后至少一小时症状仍持续改善。
织物高压舱内模拟下降对急性高原病的即刻缓解效果与氧疗相同。
